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    Nordic OCD and Related Disorders Consortium: Rationale, design, and methods

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    Authors
    Mataix-Cols, David
    Hansen, Bjarne
    Mattheisen, Manuel
    Karlsson, Elinor K.
    Addington, Anjene M.
    Boberg, Julia
    Djurfeldt, Diana R.
    Halvorsen, Matthew
    Lichtenstein, Paul
    Solem, Stian
    Lindblad-Toh, Kerstin
    Haavik, Jan
    Kvale, Gerd
    Ruck, Christian
    Crowley, James J.
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    UMass Chan Affiliations
    Program in Molecular Medicine
    Program in Bioinformatics and Integrative Biology
    Document Type
    Journal Article
    Publication Date
    2019-08-19
    Keywords
    Denmark
    GWAS
    Norway
    OCD
    Sweden
    genetic
    Computational Biology
    Genomics
    Integrative Biology
    Medical Genetics
    Mental Disorders
    Nervous System Diseases
    Psychiatry and Psychology
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    Link to Full Text
    https://doi.org/10.1002/ajmg.b.32756
    Abstract
    Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder, yet its etiology is unknown and treatment outcomes could be improved if biological targets could be identified. Unfortunately, genetic findings for OCD are lagging behind other psychiatric disorders. Thus, there is a pressing need to understand the causal mechanisms implicated in OCD in order to improve clinical outcomes and to reduce morbidity and societal costs. Specifically, there is a need for a large-scale, etiologically informative genetic study integrating genetic and environmental factors that presumably interact to cause the condition. The Nordic countries provide fertile ground for such a study, given their detailed population registers, national healthcare systems and active specialist clinics for OCD. We thus formed the Nordic OCD and Related Disorders Consortium (NORDiC, www.crowleylab.org/nordic), and with the support of NIMH and the Swedish Research Council, have begun to collect a large, richly phenotyped and genotyped sample of OCD cases. Our specific aims are geared toward answering a number of key questions regarding the biology, etiology, and treatment of OCD. This article describes and discusses the rationale, design, and methodology of NORDiC, including details on clinical measures and planned genomic analyses.
    Source

    Am J Med Genet B Neuropsychiatr Genet. 2019 Aug 19. doi: 10.1002/ajmg.b.32756. [Epub ahead of print] Link to article on publisher's site

    DOI
    10.1002/ajmg.b.32756
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/25859
    PubMed ID
    31424634
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    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1002/ajmg.b.32756
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