Nordic OCD and Related Disorders Consortium: Rationale, design, and methods
Authors
Mataix-Cols, DavidHansen, Bjarne
Mattheisen, Manuel
Karlsson, Elinor K
Addington, Anjene M.
Boberg, Julia
Djurfeldt, Diana R.
Halvorsen, Matthew
Lichtenstein, Paul
Solem, Stian
Lindblad-Toh, Kerstin
Haavik, Jan
Kvale, Gerd
Ruck, Christian
Crowley, James J.
UMass Chan Affiliations
Program in Molecular MedicineProgram in Bioinformatics and Integrative Biology
Document Type
Journal ArticlePublication Date
2019-08-19Keywords
DenmarkGWAS
Norway
OCD
Sweden
genetic
Computational Biology
Genomics
Integrative Biology
Medical Genetics
Mental Disorders
Nervous System Diseases
Psychiatry and Psychology
Metadata
Show full item recordAbstract
Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder, yet its etiology is unknown and treatment outcomes could be improved if biological targets could be identified. Unfortunately, genetic findings for OCD are lagging behind other psychiatric disorders. Thus, there is a pressing need to understand the causal mechanisms implicated in OCD in order to improve clinical outcomes and to reduce morbidity and societal costs. Specifically, there is a need for a large-scale, etiologically informative genetic study integrating genetic and environmental factors that presumably interact to cause the condition. The Nordic countries provide fertile ground for such a study, given their detailed population registers, national healthcare systems and active specialist clinics for OCD. We thus formed the Nordic OCD and Related Disorders Consortium (NORDiC, www.crowleylab.org/nordic), and with the support of NIMH and the Swedish Research Council, have begun to collect a large, richly phenotyped and genotyped sample of OCD cases. Our specific aims are geared toward answering a number of key questions regarding the biology, etiology, and treatment of OCD. This article describes and discusses the rationale, design, and methodology of NORDiC, including details on clinical measures and planned genomic analyses.Source
Am J Med Genet B Neuropsychiatr Genet. 2019 Aug 19. doi: 10.1002/ajmg.b.32756. [Epub ahead of print] Link to article on publisher's site
DOI
10.1002/ajmg.b.32756Permanent Link to this Item
http://hdl.handle.net/20.500.14038/25859PubMed ID
31424634Related Resources
ae974a485f413a2113503eed53cd6c53
10.1002/ajmg.b.32756