Mapping Billions of Short Reads to a Reference Genome
| dc.contributor.author | Hung, Jui-Hung | |
| dc.contributor.author | Weng, Zhiping | |
| dc.date | 2022-08-11T08:07:59.000 | |
| dc.date.accessioned | 2022-08-23T15:38:31Z | |
| dc.date.available | 2022-08-23T15:38:31Z | |
| dc.date.issued | 2016-01-03 | |
| dc.date.submitted | 2017-01-27 | |
| dc.identifier.citation | Cold Spring Harb Protoc. 2017 Jan 3;2017(1):pdb.top093153. doi: 10.1101/pdb.top093153. <a href="http://dx.doi.org/10.1101/pdb.top093153">Link to article on publisher's site</a> | |
| dc.identifier.issn | 1559-6095 (Linking) | |
| dc.identifier.doi | 10.1101/pdb.top093153 | |
| dc.identifier.pmid | 27574203 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14038/25950 | |
| dc.description.abstract | Rapid development and commercialization of instruments that can accurately, rapidly, and cheaply sequence billions of DNA bases is revolutionizing molecular biology and medicine. Because a reference genome is usually available, the first bioinformatics challenge presented by the new generation of high-throughput sequencers is the genome mapping problem, where each read is mapped to a reference genome to reveal its location(s). An introduction to mapping algorithms, as well as factors that influence their results, is provided here. | |
| dc.language.iso | en_US | |
| dc.relation | <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=27574203&dopt=Abstract">Link to Article in PubMed</a> | |
| dc.relation.url | http://dx.doi.org/10.1101/pdb.top093153 | |
| dc.subject | Bioinformatics | |
| dc.subject | Computational Biology | |
| dc.subject | Genomics | |
| dc.subject | Molecular Biology | |
| dc.title | Mapping Billions of Short Reads to a Reference Genome | |
| dc.type | Journal Article | |
| dc.source.journaltitle | Cold Spring Harbor protocols | |
| dc.source.volume | 2017 | |
| dc.source.issue | 1 | |
| dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/bioinformatics_pubs/90 | |
| dc.identifier.contextkey | 9590760 | |
| html.description.abstract | <p>Rapid development and commercialization of instruments that can accurately, rapidly, and cheaply sequence billions of DNA bases is revolutionizing molecular biology and medicine. Because a reference genome is usually available, the first bioinformatics challenge presented by the new generation of high-throughput sequencers is the genome mapping problem, where each read is mapped to a reference genome to reveal its location(s). An introduction to mapping algorithms, as well as factors that influence their results, is provided here.</p> | |
| dc.identifier.submissionpath | bioinformatics_pubs/90 | |
| dc.contributor.department | Department of Biochemistry and Molecular Pharmacology | |
| dc.contributor.department | Program in Bioinformatics and Integrative Biology | |
| dc.source.pages | pdb.top093153 |