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dc.contributor.authorHung, Jui-Hung
dc.contributor.authorWeng, Zhiping
dc.date2022-08-11T08:07:59.000
dc.date.accessioned2022-08-23T15:38:31Z
dc.date.available2022-08-23T15:38:31Z
dc.date.issued2016-11-01
dc.date.submitted2017-01-27
dc.identifier.citationCold Spring Harb Protoc. 2016 Nov 1;2016(11):pdb.top093070. doi: 10.1101/pdb.top093070. <a href="http://dx.doi.org/10.1101/pdb.top093070">Link to article on publisher's site</a>
dc.identifier.issn1559-6095 (Linking)
dc.identifier.doi10.1101/pdb.top093070
dc.identifier.pmid27574200
dc.identifier.urihttp://hdl.handle.net/20.500.14038/25952
dc.description.abstractBioinformatics was brought into the spotlight in the late 1990s through the Human Genome Project. With the rapid accumulation of completed genomes, it was soon realized that for the vast majority of the newly identified genes and other functional regions of the genomes there were no other biological data. One way of inferring biological function is through homology: Because homologous genes have a common evolutionary descent, they are likely to have the same biological function. A large number of bioinformatics tools have been designed for rapidly and accurately comparing sequences of genes or proteins, comparing gene sequences with genomes, and comparing genomes. Two widely used tools for sequence alignment and homology searches, BLAST and ClustalW, are introduced here.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=27574200&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1101/pdb.top093070
dc.subjectBioinformatics
dc.subjectComputational Biology
dc.subjectGenomics
dc.titleSequence Alignment and Homology Search
dc.typeArticle
dc.source.journaltitleCold Spring Harbor protocols
dc.source.volume2016
dc.source.issue11
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/bioinformatics_pubs/93
dc.identifier.contextkey9590765
html.description.abstract<p>Bioinformatics was brought into the spotlight in the late 1990s through the Human Genome Project. With the rapid accumulation of completed genomes, it was soon realized that for the vast majority of the newly identified genes and other functional regions of the genomes there were no other biological data. One way of inferring biological function is through homology: Because homologous genes have a common evolutionary descent, they are likely to have the same biological function. A large number of bioinformatics tools have been designed for rapidly and accurately comparing sequences of genes or proteins, comparing gene sequences with genomes, and comparing genomes. Two widely used tools for sequence alignment and homology searches, BLAST and ClustalW, are introduced here.</p>
dc.identifier.submissionpathbioinformatics_pubs/93
dc.contributor.departmentDepartment of Biochemistry and Molecular Pharmacology
dc.contributor.departmentProgram in Bioinformatics and Integrative Biology
dc.source.pagespdb.top093070


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