Ancestry-inclusive dog genomics challenges popular breed stereotypes
White, Michelle E
Lord, Kathryn A.
Karlsson, Elinor K
Student AuthorsKathleen Morrill
Academic ProgramNeuroscience; Bioinformatics and Computational Biology
UMass Chan AffiliationsProgram in Molecular Medicine
Morningside Graduate School of Biomedical Sciences
Program in Bioinformatics and Integrative Biology
Document TypeJournal Article
KeywordsBiochemistry, Biophysics, and Structural Biology
Ecology and Evolutionary Biology
Genetics and Genomics
MetadataShow full item record
AbstractBehavioral genetics in dogs has focused on modern breeds, which are isolated subgroups with distinctive physical and, purportedly, behavioral characteristics. We interrogated breed stereotypes by surveying owners of 18,385 purebred and mixed-breed dogs and genotyping 2155 dogs. Most behavioral traits are heritable [heritability (h(2)) > 25%], and admixture patterns in mixed-breed dogs reveal breed propensities. Breed explains just 9% of behavioral variation in individuals. Genome-wide association analyses identify 11 loci that are significantly associated with behavior, and characteristic breed behaviors exhibit genetic complexity. Behavioral loci are not unusually differentiated in breeds, but breed propensities align, albeit weakly, with ancestral function. We propose that behaviors perceived as characteristic of modern breeds derive from thousands of years of polygenic adaptation that predates breed formation, with modern breeds distinguished primarily by aesthetic traits.
Morrill K, Hekman J, Li X, McClure J, Logan B, Goodman L, Gao M, Dong Y, Alonso M, Carmichael E, Snyder-Mackler N, Alonso J, Noh HJ, Johnson J, Koltookian M, Lieu C, Megquier K, Swofford R, Turner-Maier J, White ME, Weng Z, Colubri A, Genereux DP, Lord KA, Karlsson EK. Ancestry-inclusive dog genomics challenges popular breed stereotypes. Science. 2022 Apr 29;376(6592):eabk0639. doi: 10.1126/science.abk0639. Epub 2022 Apr 29. PMID: 35482869. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/25969
Full author list omitted for brevity. For the full list of authors, see article.
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