Show simple item record

dc.contributor.authorMorrill, Kathleen
dc.contributor.authorLi, Xue
dc.contributor.authorMcClure, Jesse
dc.contributor.authorLogan, Brittney
dc.contributor.authorGao, Mingshi
dc.contributor.authorDong, Yinan
dc.contributor.authorCarmichael, Elena
dc.contributor.authorWhite, Michelle E
dc.contributor.authorWeng, Zhiping
dc.contributor.authorColubri, Andres
dc.contributor.authorLord, Kathryn A.
dc.contributor.authorKarlsson, Elinor K
dc.date2022-08-11T08:08:00.000
dc.date.accessioned2022-08-23T15:38:36Z
dc.date.available2022-08-23T15:38:36Z
dc.date.issued2022-04-29
dc.date.submitted2022-07-05
dc.identifier.citation<p>Morrill K, Hekman J, Li X, McClure J, Logan B, Goodman L, Gao M, Dong Y, Alonso M, Carmichael E, Snyder-Mackler N, Alonso J, Noh HJ, Johnson J, Koltookian M, Lieu C, Megquier K, Swofford R, Turner-Maier J, White ME, Weng Z, Colubri A, Genereux DP, Lord KA, Karlsson EK. Ancestry-inclusive dog genomics challenges popular breed stereotypes. Science. 2022 Apr 29;376(6592):eabk0639. doi: 10.1126/science.abk0639. Epub 2022 Apr 29. PMID: 35482869. <a href="https://doi.org/10.1126/science.abk0639">Link to article on publisher's site</a></p>
dc.identifier.issn0036-8075 (Linking)
dc.identifier.doi10.1126/science.abk0639
dc.identifier.pmid35482869
dc.identifier.urihttp://hdl.handle.net/20.500.14038/25969
dc.description<p>Full author list omitted for brevity. For the full list of authors, see article.</p>
dc.description.abstractBehavioral genetics in dogs has focused on modern breeds, which are isolated subgroups with distinctive physical and, purportedly, behavioral characteristics. We interrogated breed stereotypes by surveying owners of 18,385 purebred and mixed-breed dogs and genotyping 2155 dogs. Most behavioral traits are heritable [heritability (h(2)) > 25%], and admixture patterns in mixed-breed dogs reveal breed propensities. Breed explains just 9% of behavioral variation in individuals. Genome-wide association analyses identify 11 loci that are significantly associated with behavior, and characteristic breed behaviors exhibit genetic complexity. Behavioral loci are not unusually differentiated in breeds, but breed propensities align, albeit weakly, with ancestral function. We propose that behaviors perceived as characteristic of modern breeds derive from thousands of years of polygenic adaptation that predates breed formation, with modern breeds distinguished primarily by aesthetic traits.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=35482869&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://doi.org/10.1126/science.abk0639
dc.subjectBiochemistry, Biophysics, and Structural Biology
dc.subjectBioinformatics
dc.subjectComputational Biology
dc.subjectEcology and Evolutionary Biology
dc.subjectGenetics and Genomics
dc.subjectIntegrative Biology
dc.subjectSystems Biology
dc.titleAncestry-inclusive dog genomics challenges popular breed stereotypes
dc.typeJournal Article
dc.source.journaltitleScience (New York, N.Y.)
dc.source.volume376
dc.source.issue6592
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/bioinformatics_pubs/180
dc.identifier.contextkey30064410
html.description.abstract<p>Behavioral genetics in dogs has focused on modern breeds, which are isolated subgroups with distinctive physical and, purportedly, behavioral characteristics. We interrogated breed stereotypes by surveying owners of 18,385 purebred and mixed-breed dogs and genotyping 2155 dogs. Most behavioral traits are heritable [heritability (h(2)) > 25%], and admixture patterns in mixed-breed dogs reveal breed propensities. Breed explains just 9% of behavioral variation in individuals. Genome-wide association analyses identify 11 loci that are significantly associated with behavior, and characteristic breed behaviors exhibit genetic complexity. Behavioral loci are not unusually differentiated in breeds, but breed propensities align, albeit weakly, with ancestral function. We propose that behaviors perceived as characteristic of modern breeds derive from thousands of years of polygenic adaptation that predates breed formation, with modern breeds distinguished primarily by aesthetic traits.</p>
dc.identifier.submissionpathbioinformatics_pubs/180
dc.contributor.departmentProgram in Molecular Medicine
dc.contributor.departmentMorningside Graduate School of Biomedical Sciences
dc.contributor.departmentProgram in Bioinformatics and Integrative Biology
dc.source.pageseabk0639
dc.contributor.studentKathleen Morrill
dc.contributor.studentXue Li
dc.contributor.studentMingshi Gao
dc.description.thesisprogramNeuroscience
dc.description.thesisprogramBioinformatics and Computational Biology


This item appears in the following Collection(s)

Show simple item record