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UMass Chan Affiliations
Institute for Drug ResistanceDepartment of Biochemistry and Molecular Pharmacology
Document Type
Journal ArticlePublication Date
2011-09-26Keywords
Drug DesignDrug Resistance, Viral
HIV Protease Inhibitors
HIV-1
Molecular Targeted Therapy
Biochemistry, Biophysics, and Structural Biology
Microbiology
Metadata
Show full item recordAbstract
Drug resistance is problematic in microbial disease, viral disease and cancer. Understanding at the outset that resistance will impact the effectiveness of any new drug that is developed for these disease categories is imperative. In this Feature, we detail approaches that have been taken with selected drug targets to reduce the susceptibility of new drugs to resistance mechanisms. We will also define the concepts of robust drugs and resilient targets, and discuss how the design of robust drugs and the selection of resilient targets can lead to successful strategies for combating resistance.Source
Drug Discov Today. 2011 Sep;16(17-18):755-61. Epub 2011 Jul 19. Link to article on publisher's siteDOI
10.1016/j.drudis.2011.07.001Permanent Link to this Item
http://hdl.handle.net/20.500.14038/26002PubMed ID
21784168Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.drudis.2011.07.001