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    The challenge of developing robust drugs to overcome resistance

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    Authors
    Anderson, Amy C.
    Pollastri, Michael P.
    Schiffer, Celia A.
    Peet, Norton P.
    UMass Chan Affiliations
    Institute for Drug Resistance
    Department of Biochemistry and Molecular Pharmacology
    Document Type
    Journal Article
    Publication Date
    2011-09-26
    Keywords
    Drug Design
    Drug Resistance, Viral
    HIV Protease Inhibitors
    HIV-1
    Molecular Targeted Therapy
    Biochemistry, Biophysics, and Structural Biology
    Microbiology
    
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    Link to Full Text
    http://dx.doi.org/10.1016/j.drudis.2011.07.001
    Abstract
    Drug resistance is problematic in microbial disease, viral disease and cancer. Understanding at the outset that resistance will impact the effectiveness of any new drug that is developed for these disease categories is imperative. In this Feature, we detail approaches that have been taken with selected drug targets to reduce the susceptibility of new drugs to resistance mechanisms. We will also define the concepts of robust drugs and resilient targets, and discuss how the design of robust drugs and the selection of resilient targets can lead to successful strategies for combating resistance.
    Source
    Drug Discov Today. 2011 Sep;16(17-18):755-61. Epub 2011 Jul 19. Link to article on publisher's site
    DOI
    10.1016/j.drudis.2011.07.001
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/26002
    PubMed ID
    21784168
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.drudis.2011.07.001
    Scopus Count
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    UMass Chan Faculty and Researcher Publications
    Schiffer Lab Publications

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