Small RNA-Directed Silencing: The Fly Finds Its Inner Fission Yeast
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UMass Chan Affiliations
Department of Biochemistry and Molecular PharmacologyDocument Type
Journal ArticlePublication Date
2013-04-22Keywords
RNA, Small InterferingBiochemistry, Biophysics, and Structural Biology
Genetics and Genomics
Molecular Genetics
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Show full item recordAbstract
Several recent studies demonstrate that piRNAs guide Piwi protein to repress transposon transcription in fly ovaries, much as fission yeast use siRNAs to silence repeat sequences. Still mysterious though is how Piwi targets euchromatic transposons for silencing, but not the specialized heterochromatic loci that produce piRNA precursors.Source
Curr Biol. 2013 Apr 22;23(8):R318-20. doi: 10.1016/j.cub.2013.03.033. Link to article on publisher's siteDOI
10.1016/j.cub.2013.03.033Permanent Link to this Item
http://hdl.handle.net/20.500.14038/26026PubMed ID
23618667Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.cub.2013.03.033