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    Mutagenesis and repair of DNA damage caused by nitrogen mustard, N,N'-bis(2-chloroethyl)-N-nitrosourea (BCNU), streptozotocin, and mitomycin C in E. coli

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    Authors
    Fram, Robert J.
    Sullivan, J.
    Marinus, Martin G.
    UMass Chan Affiliations
    Department of Biochemistry and Molecular Pharmacology
    Document Type
    Journal Article
    Publication Date
    1986-11-01
    Keywords
    Carmustine
    *DNA Damage
    *DNA Glycosylases
    DNA Repair
    DNA, Bacterial
    Escherichia coli
    Genes, Bacterial
    Mechlorethamine
    Methyltransferases
    Mitomycin
    Mitomycins
    N-Glycosyl Hydrolases
    Rec A Recombinases
    SOS Response (Genetics)
    Site-Specific DNA-Methyltransferase (Adenine-Specific)
    Streptozocin
    Biochemistry, Biophysics, and Structural Biology
    Pharmacology, Toxicology and Environmental Health
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    Link to Full Text
    https://doi.org/10.1016/0167-8817(86)90023-4
    Abstract
    Cytotoxicity and mutagenesis by streptozotocin, BCNU, nitrogen mustard, and mitomycin C were evaluated in E. coli mutants deficient in SOS repair, SOS-mediated mutagenesis, the adaptive response, and mutants that engage in aberrant mismatch repair. The results demonstrate that premutagenic lesions are caused by nitrogen mustard, BCNU and streptozotocin that are not repaired by ada or recognized by umuDC. Further, recA mutants were hypomutable after exposure to nitrogen mustard, BCNU, and streptozotocin compared to wild type. With the exception of the monofunctional nitrosourea, streptozotocin, both recA and uvrA gene products contribute to the repair of DNA damage caused by the alkylating agents tested. In the case of streptozotocin, although recA mutants were more sensitive than wild type, uvrA mutants were not. Moreover, while ada and alkA E. coli mutants showed increased sensitivity to streptozotocin, they were not more sensitive to the other alkylating agents evaluated.
    Source

    Mutat Res. 1986 Nov;166(3):299-42.

    DOI
    10.1016/0167-8817(86)90023-4
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/26087
    PubMed ID
    2946949
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    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1016/0167-8817(86)90023-4
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