ATP-Dependent Sugar Transport Complexity in Human Erythrocytes
| dc.contributor.author | Leitch, Jeffry M. | |
| dc.contributor.author | Carruthers, Anthony | |
| dc.date | 2022-08-11T08:08:01.000 | |
| dc.date.accessioned | 2022-08-23T15:39:15Z | |
| dc.date.available | 2022-08-23T15:39:15Z | |
| dc.date.issued | 2007-02-13 | |
| dc.date.submitted | 2009-02-18 | |
| dc.identifier.citation | Am J Physiol Cell Physiol. 2007 Feb;292(2):C974-86. Epub 2006 Aug 23. <a href="http://dx.doi.org/10.1152/ajpcell.00335.2006">Link to article on publisher's site</a> | |
| dc.identifier.doi | 10.1152/ajpcell.00335.2006 | |
| dc.identifier.pmid | 16928769 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14038/26122 | |
| dc.description.abstract | Human erythrocyte glucose sugar transport was examined in resealed red cell ghosts under equilibrium exchange conditions ([sugar](intracellular) = [sugar](extracellular), where brackets indicate concentration). Exchange 3-O-methylglucose (3MG) import and export are monophasic in the absence of cytoplasmic ATP but are biphasic when ATP is present. Biphasic exchange is observed as the rapid filling of a large compartment (66% cell volume) followed by the slow filling of the remaining cytoplasmic space. Biphasic exchange at 20 mM 3MG eliminates the possibility that the rapid exchange phase represents ATP-dependent 3MG binding to the glucose transport protein (GLUT1; cellular [GLUT1] of | |
| dc.language.iso | en_US | |
| dc.relation | <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16928769&dopt=Abstract">Link to article in PubMed</a> | |
| dc.relation.url | http://dx.doi.org/10.1152/ajpcell.00335.2006 | |
| dc.subject | 3-O-Methylglucose | |
| dc.subject | Adenosine Triphosphate | |
| dc.subject | Biological Transport | |
| dc.subject | Cell Size | |
| dc.subject | Cytoplasm | |
| dc.subject | Equilibrative Nucleoside Transporter 1 | |
| dc.subject | Erythrocyte Membrane | |
| dc.subject | Erythrocytes | |
| dc.subject | Glucose | |
| dc.subject | Glucose Transporter Type 1 | |
| dc.subject | Humans | |
| dc.subject | Microscopy, Electron, Scanning | |
| dc.subject | Models, Biological | |
| dc.subject | Uridine | |
| dc.subject | Membrane transport; erythrocytes; GLUT1 | |
| dc.subject | Medical Biochemistry | |
| dc.subject | Medical Biophysics | |
| dc.subject | Physiological Processes | |
| dc.title | ATP-Dependent Sugar Transport Complexity in Human Erythrocytes | |
| dc.type | Journal Article | |
| dc.source.journaltitle | American journal of physiology. Cell physiology | |
| dc.source.volume | 292 | |
| dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/bmp_pp/61 | |
| dc.identifier.contextkey | 724049 | |
| html.description.abstract | <p>Human erythrocyte glucose sugar transport was examined in resealed red cell ghosts under equilibrium exchange conditions ([sugar](intracellular) = [sugar](extracellular), where brackets indicate concentration). Exchange 3-O-methylglucose (3MG) import and export are monophasic in the absence of cytoplasmic ATP but are biphasic when ATP is present. Biphasic exchange is observed as the rapid filling of a large compartment (66% cell volume) followed by the slow filling of the remaining cytoplasmic space. Biphasic exchange at 20 mM 3MG eliminates the possibility that the rapid exchange phase represents ATP-dependent 3MG binding to the glucose transport protein (GLUT1; cellular [GLUT1] of </p> | |
| dc.identifier.submissionpath | bmp_pp/61 | |
| dc.contributor.department | Department of Biochemistry and Molecular Pharmacology | |
| dc.contributor.department | Graduate School of Biomedical Sciences | |
| dc.source.pages | C974-C986 |
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