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    Role of the E-cadherin/alpha-catenin complex in modulating cell-cell and cell-matrix adhesive properties of invasive colon carcinoma cells

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    Authors
    Breen, Ellen C.
    Steele, Glenn D. Jr.
    Mercurio, Arthur M.
    UMass Chan Affiliations
    Department of Cancer Biology
    Document Type
    Journal Article
    Publication Date
    1995-09-01
    Keywords
    Basement Membrane
    Cadherins
    Calcium
    Cell Adhesion
    Cell Aggregation
    Cell Movement
    Collagen
    Colonic Neoplasms
    Cytoskeletal Proteins
    Extracellular Matrix
    Humans
    Laminin
    Neoplasm Invasiveness
    Stromal Cells
    Transfection
    Tumor Cells, Cultured
    alpha Catenin
    Cancer Biology
    Neoplasms
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    Link to Full Text
    http://dx.doi.org/10.1007/BF02306369
    Abstract
    BACKGROUND: The clinical behavior of colorectal cancer depends on its ability to invade and metastasize. Metastatic cells must dissociate from other cells and invade through basement membrane and stroma. Cell-cell adhesion in epithelial cells is mediated by the cell surface protein E-cadherin in association with alpha- and beta-catenin, which link E-cadherin to the cytoskeleton. Decreased cell-cell adhesion and increased motility on laminin have been correlated with more poorly differentiated and aggressive carcinomas. METHODS: In this study, the RKO cell line, previously shown by us to lack E-cadherin expression, was transfected with the complementary DNA for E-cadherin. The transfectants were selected for high levels of surface expression by sequential FACS and examined in functional assays. RESULTS: In comparison to control transfectants, the E-cadherin transfectants exhibited a more epithelial-like morphology, a 30% increase in Ca(2+)-dependent cell-cell aggregation, and a markedly reduced motility on the matrix proteins, collagen I and laminin. CONCLUSIONS: These data demonstrate that correction of a defect in the cadherin/catenin cell-cell adhesion complex, often found in poorly differentiated and highly invasive tumors, facilitates increased cell-cell adhesion and retards tumor cell migration on basement membrane and stromal proteins.
    Source
    Ann Surg Oncol. 1995 Sep;2(5):378-85.
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/26219
    PubMed ID
    7496831
    Related Resources
    Link to Article in PubMed
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    UMass Chan Faculty and Researcher Publications

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