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    The integrin alpha 6 beta 4 and the biology of carcinoma

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    Authors
    Rabinovitz, Isaac
    Mercurio, Arthur M.
    UMass Chan Affiliations
    Department of Cancer Biology
    Document Type
    Journal Article
    Publication Date
    1996-01-01
    Keywords
    Antigens, Surface
    Apoptosis
    Basement Membrane
    Humans
    Integrin alpha6beta4
    Integrins
    Laminin
    Neoplasm Invasiveness
    Neoplasm Metastasis
    *Neoplasms
    Receptors, Laminin
    Signal Transduction
    Amino Acids, Peptides, and Proteins
    Cancer Biology
    Neoplasms
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    Link to Full Text
    https://doi.org/10.1139/o96-087
    Abstract
    The integrin family of adhesion receptors plays a major role in epithelial organization and function. Moreover, the altered expression and function of specific integrins most likely contributes significantly to carcinoma progression. The integrin alpha 6 beta 4, the focus of this review, is a receptor for several members of the laminin family and is preferentially expressed at the basal surface of most epithelia, where it contributes to basement membrane interactions. Mounting evidence suggests that the alpha 6 beta 4 integrin plays a key role in carcinoma cell biology. Several histopathological studies have established a correlation between alpha 6 beta 4 integrin expression and tumor progression. The importance of alpha 6 beta 4 expression in tumors in underscored by the findings that invading fronts of several carcinomas are enriched in the expression of alpha 6 beta 4 integrin ligands, such as laminin-1 and laminin-5. The participation of the alpha 6 beta 4 integrin in invasion is supported further by in vitro functional studies using carcinoma cells that have been transfected with the beta 4 cDNA. The mechanisms by which alpha 6 beta 4 contributes to tumor progression are probably related to its mechanical and signaling properties and are currently under intense study.
    Source

    Biochem Cell Biol. 1996;74(6):811-21.

    DOI
    10.1139/o96-087
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/26226
    PubMed ID
    9164650
    Related Resources

    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1139/o96-087
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