Autocrine signaling in carcinoma: VEGF and the alpha6beta4 integrin
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UMass Chan Affiliations
Department of Cancer BiologyDocument Type
Journal ArticlePublication Date
2004-03-17Keywords
*Autocrine CommunicationCarcinoma
Humans
Integrin alpha6beta4
Signal Transduction
Vascular Endothelial Growth Factor A
Cancer Biology
Neoplasms
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Show full item recordAbstract
This review highlights an emerging function for vascular endothelial growth factor (VEGF) in carcinoma and discusses mechanisms involved in the elaboration of VEGF autocrine loops. Evidence is provided that autocrine VEGF contributes to the two major components of invasive carcinoma: survival and migration. Moreover, the findings discussed support the hypothesis that carcinoma progression selects for cells that depend on VEGF as a survival factor. Furthermore, a related hypothesis, which is developed, is that the function of the alpha6beta4 integrin, which has been implicated in carcinoma progression, is linked to its ability to regulate VEGF translation and, consequently, autocrine VEGF signaling. The findings reviewed challenge the notion that the function of VEGF in cancer is limited to angiogenesis and suggest that VEGF and VEGF receptor-based therapeutics, in addition to targeting angiogenesis, may also impair tumor cell survival and invasion directly.Source
Semin Cancer Biol. 2004 Apr;14(2):115-22. Link to article on publisher's siteDOI
10.1016/j.semcancer.2003.09.016Permanent Link to this Item
http://hdl.handle.net/20.500.14038/26255PubMed ID
15018895Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.semcancer.2003.09.016