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dc.contributor.authorDeClerck, Yves A.
dc.contributor.authorMercurio, Arthur M.
dc.contributor.authorStack, M. Sharon
dc.contributor.authorChapman, Harold D.
dc.contributor.authorZutter, Mary M.
dc.contributor.authorMuschel, Ruth J.
dc.contributor.authorRaz, Avraham
dc.contributor.authorMatrisian, Lynn M.
dc.contributor.authorSloane, Bonnie F.
dc.contributor.authorNoel, Agnes
dc.contributor.authorHendrix, Mary J.
dc.contributor.authorCoussens, Lisa
dc.contributor.authorPadarathsingh, Martin
dc.date2022-08-11T08:08:02.000
dc.date.accessioned2022-08-23T15:39:48Z
dc.date.available2022-08-23T15:39:48Z
dc.date.issued2004-03-25
dc.date.submitted2010-11-07
dc.identifier.citation<p>Am J Pathol. 2004 Apr;164(4):1131-9.</p>
dc.identifier.issn0002-9440 (Linking)
dc.identifier.doi10.1016/S0002-9440(10)63200-2
dc.identifier.pmid15039201
dc.identifier.urihttp://hdl.handle.net/20.500.14038/26256
dc.description.abstractThe role of the extracellular matrix (ECM) in the tumor microenvironment is not limited to being a barrier against tumor invasion. The ECM is a reservoir of cell binding proteins and growth factors that affect tumor cell behavior. It is also substantially modified by proteases produced by tumor cells or stroma cells. As a result of the activity of these proteases, cell-cell and cell-ECM interactions are altered, new biologically active ECM molecules are generated, and the bioavailability and activity of many growth factors, growth factor receptors, and cytokines are modified. ECM-degrading proteases also play a critical role in angiogenesis, where they can act as positive as well as negative regulators of endothelial cell proliferation and vascular morphogenesis. This review article summarizes some of the most relevant findings made over the recent years that were discussed at a workshop organized by the Path B Study Section of the National Institutes of Health in October 2002.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=15039201&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1615345
dc.subjectAnimals
dc.subjectCell Communication
dc.subjectEndopeptidases
dc.subjectExtracellular Matrix
dc.subjectHumans
dc.subjectNeoplasms
dc.subjectCancer Biology
dc.subjectEnzymes and Coenzymes
dc.subjectNeoplasms
dc.titleProteases, extracellular matrix, and cancer: a workshop of the path B study section
dc.typeArticle
dc.source.journaltitleThe American journal of pathology
dc.source.volume164
dc.source.issue4
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/cancerbiology_pp/170
dc.identifier.contextkey1633395
html.description.abstract<p>The role of the extracellular matrix (ECM) in the tumor microenvironment is not limited to being a barrier against tumor invasion. The ECM is a reservoir of cell binding proteins and growth factors that affect tumor cell behavior. It is also substantially modified by proteases produced by tumor cells or stroma cells. As a result of the activity of these proteases, cell-cell and cell-ECM interactions are altered, new biologically active ECM molecules are generated, and the bioavailability and activity of many growth factors, growth factor receptors, and cytokines are modified. ECM-degrading proteases also play a critical role in angiogenesis, where they can act as positive as well as negative regulators of endothelial cell proliferation and vascular morphogenesis. This review article summarizes some of the most relevant findings made over the recent years that were discussed at a workshop organized by the Path B Study Section of the National Institutes of Health in October 2002.</p>
dc.identifier.submissionpathcancerbiology_pp/170
dc.contributor.departmentDepartment of Cancer Biology
dc.source.pages1131-9


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