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Integrin laminin receptors and breast carcinoma progression

dc.contributor.authorMercurio, Arthur M.
dc.contributor.authorBachelder, Robin E.
dc.contributor.authorChung, Jun
dc.contributor.authorO'Connor, Kathleen L.
dc.contributor.authorRabinovitz, Isaac
dc.contributor.authorShaw, Leslie M.
dc.contributor.authorTani, Taneli
dc.date2022-08-11T08:08:02.000
dc.date.accessioned2022-08-23T15:39:54Z
dc.date.available2022-08-23T15:39:54Z
dc.date.issued2001-09-08
dc.date.submitted2010-11-12
dc.identifier.citationJ Mammary Gland Biol Neoplasia. 2001 Jul;6(3):299-309.
dc.identifier.issn1083-3021 (Linking)
dc.identifier.pmid11547899
dc.identifier.urihttp://hdl.handle.net/20.500.14038/26281
dc.description.abstractThis review explores the mechanistic basis of breast carcinoma progression by focusing on the contribution of integrins. Integrins are essential for progression not only for their ability to mediate physical interactions with extracellular matrices but also for their ability to regulate signaling pathways that control actin dynamics and cell movement, as well as for growth and survival. Our comments center on the alpha6 integrins (alpha6beta1 and alpha6beta4), which are receptors for the laminin family of basement membrane components. Numerous studies have implicated these integrins in breast cancer progression and have provided a rationale for studying the mechanistic basis of their contribution to aggressive disease. Recent work by our group and others on mechanisms of breast carcinoma invasion and survival that are influenced by the alpha6 integrins are discussed.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=11547899&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1023/A:1011323608064
dc.subject1-Phosphatidylinositol 3-Kinase
dc.subjectAntigens, Neoplasm
dc.subjectAntigens, Surface
dc.subjectBreast Neoplasms
dc.subjectCell Movement
dc.subjectDisease Progression
dc.subjectFemale
dc.subjectHumans
dc.subjectIntegrin alpha6beta4
dc.subjectIntegrins
dc.subjectSurvival Rate
dc.subjectCancer Biology
dc.subjectNeoplasms
dc.titleIntegrin laminin receptors and breast carcinoma progression
dc.typeJournal Article
dc.source.journaltitleJournal of mammary gland biology and neoplasia
dc.source.volume6
dc.source.issue3
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/cancerbiology_pp/197
dc.identifier.contextkey1640420
html.description.abstract<p>This review explores the mechanistic basis of breast carcinoma progression by focusing on the contribution of integrins. Integrins are essential for progression not only for their ability to mediate physical interactions with extracellular matrices but also for their ability to regulate signaling pathways that control actin dynamics and cell movement, as well as for growth and survival. Our comments center on the alpha6 integrins (alpha6beta1 and alpha6beta4), which are receptors for the laminin family of basement membrane components. Numerous studies have implicated these integrins in breast cancer progression and have provided a rationale for studying the mechanistic basis of their contribution to aggressive disease. Recent work by our group and others on mechanisms of breast carcinoma invasion and survival that are influenced by the alpha6 integrins are discussed.</p>
dc.identifier.submissionpathcancerbiology_pp/197
dc.contributor.departmentDepartment of Cancer Biology
dc.source.pages299-309


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