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dc.contributor.authorMercurio, Arthur M.
dc.contributor.authorRabinovitz, Isaac
dc.date2022-08-11T08:08:02.000
dc.date.accessioned2022-08-23T15:39:55Z
dc.date.available2022-08-23T15:39:55Z
dc.date.issued2001-04-27
dc.date.submitted2010-11-12
dc.identifier.citationSemin Cancer Biol. 2001 Apr;11(2):129-41. <a href="http://dx.doi.org/10.1006/scbi.2000.0364">Link to article on publisher's site</a>
dc.identifier.issn1044-579X (Linking)
dc.identifier.doi10.1006/scbi.2000.0364
dc.identifier.pmid11322832
dc.identifier.urihttp://hdl.handle.net/20.500.14038/26282
dc.description.abstractThis review explores the mechanistic basis of carcinoma migration and invasion by focusing on the contribution of integrins. Integrins are essential for invasion not only for their ability to mediate physical interactions with extracellular matrices, but also for their ability to regulate signaling pathways that control actin dynamics and cell movement, as well as for growth and survival. Our comments center on a unique member of the integrin family, the alpha 6 beta 4 integrin, which is a receptor for the laminin family of basement membrane components. Numerous studies have implicated this integrin in the invasion of solid tumors and have provided a rationale for studying the mechanistic basis of its contribution to the invasive process. Such studies have revealed novel insights into the mechanism of carcinoma invasion that involve both the dynamics of cell migration and signaling pathways that regulate this migration.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=11322832&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1006/scbi.2000.0364
dc.subject1-Phosphatidylinositol 3-Kinase
dc.subjectAntigens, Neoplasm
dc.subjectAntigens, Surface
dc.subjectCell Movement
dc.subjectCyclic AMP
dc.subjectHumans
dc.subjectIntegrin alpha6beta4
dc.subjectIntegrins
dc.subject*Neoplasm Invasiveness
dc.subjectNeoplasms
dc.subjectSignal Transduction
dc.subjectCancer Biology
dc.subjectNeoplasms
dc.titleTowards a mechanistic understanding of tumor invasion--lessons from the alpha6beta 4 integrin
dc.typeJournal Article
dc.source.journaltitleSeminars in cancer biology
dc.source.volume11
dc.source.issue2
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/cancerbiology_pp/198
dc.identifier.contextkey1640421
html.description.abstract<p>This review explores the mechanistic basis of carcinoma migration and invasion by focusing on the contribution of integrins. Integrins are essential for invasion not only for their ability to mediate physical interactions with extracellular matrices, but also for their ability to regulate signaling pathways that control actin dynamics and cell movement, as well as for growth and survival. Our comments center on a unique member of the integrin family, the alpha 6 beta 4 integrin, which is a receptor for the laminin family of basement membrane components. Numerous studies have implicated this integrin in the invasion of solid tumors and have provided a rationale for studying the mechanistic basis of its contribution to the invasive process. Such studies have revealed novel insights into the mechanism of carcinoma invasion that involve both the dynamics of cell migration and signaling pathways that regulate this migration.</p>
dc.identifier.submissionpathcancerbiology_pp/198
dc.contributor.departmentDepartment of Cancer Biology
dc.source.pages129-41


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