Vascular endothelial growth factor is an autocrine survival factor for neuropilin-expressing breast carcinoma cells
Authors
Bachelder, Robin E.Crago, Aimee
Chung, Jun
Wendt, Melissa A.
Shaw, Leslie M.
Robinson, Gregory
Mercurio, Arthur M.
UMass Chan Affiliations
Department of Cancer BiologyDocument Type
Journal ArticlePublication Date
2001-08-02Keywords
1-Phosphatidylinositol 3-KinaseApoptosis
Breast Neoplasms
Cell Hypoxia
Cell Survival
Chromones
Endothelial Growth Factors
Enzyme Activation
Enzyme Inhibitors
Humans
Lymphokines
Morpholines
Nerve Tissue Proteins
Neuropilin-1
Signal Transduction
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
Cancer Biology
Neoplasms
Metadata
Show full item recordAbstract
We identify a novel function for the vascular endothelial growth factor (VEGF) in its ability to stimulate an autocrine signaling pathway in metastatic breast carcinoma cells that is essential for their survival. Suppression of VEGF expression in metastatic cells in vitro induced their apoptosis, in addition to inhibiting the constitutively elevated phosphatidylinositol 3'-kinase activity that is characteristic of these cells and important for their survival. Hypoxia enhanced the survival of metastatic cells by increasing VEGF expression. The importance of the VEGF receptor neuropilin was indicated by the ability of a neuropilin-binding VEGF isoform to enhance breast carcinoma survival. Moreover, the expression of neuropilin in neuropilin-deficient breast carcinoma cells protected them from apoptosis. The identification of this VEGF autocrine signaling pathway has important implications for tumor metastasis and therapeutic intervention.Source
Cancer Res. 2001 Aug 1;61(15):5736-40.Permanent Link to this Item
http://hdl.handle.net/20.500.14038/26286PubMed ID
11479209Related Resources
Link to Article in PubMedCollections
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