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    The alpha 6 beta 4 integrin and epithelial cell migration

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    Authors
    Mercurio, Arthur M.
    Rabinovitz, Isaac
    Shaw, Leslie M.
    UMass Chan Affiliations
    Department of Cancer Biology
    Document Type
    Journal Article
    Publication Date
    2001-10-01
    Keywords
    Antigens, Surface
    Cell Movement
    Epithelial Cells
    Integrins
    Cancer Biology
    Neoplasms
    
    Metadata
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    Link to Full Text
    http://dx.doi.org/10.1016/S0955-0674(00)00249-0
    Abstract
    Although the involvement of alpha 6 beta 4, an integrin laminin receptor, in hemidesmosome organization has dominated the study of this integrin, recent studies are revealing novel functions for alpha 6 beta 4 in the migration of epithelial and carcinoma cells. The engagement of laminin by alpha 6 beta 4 can stabilize actin-rich protrusions and mediate traction forces necessary for cell movement. This integrin also has a significant impact on signaling molecules that stimulate migration and invasion, especially PI3-K and Rho GTPases. Activation of PI3-K by alpha 6 beta 4 enhances the formation of actin protrusions, and it may stimulate the function of other integrins, such as alpha 3 beta 1, that are also important for epithelial migration. Signaling through alpha 6 beta 4 may not always depend on the adhesive functions of this integrin, a possibility that has profound implications for migration and invasion because it implies that the ability of alpha 6 beta 4 to stimulate these processes is not limited to specific matrix environments.
    Source
    Curr Opin Cell Biol. 2001 Oct;13(5):541-5.
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/26291
    PubMed ID
    11544021
    Related Resources
    Link to article in PubMed
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    UMass Chan Faculty and Researcher Publications

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