UMass Chan Affiliations
Department of Cancer BiologyDocument Type
Journal ArticlePublication Date
2013-12-01Keywords
AnimalsAntineoplastic Agents
Autocrine Communication
Capillary Permeability
Humans
Molecular Targeted Therapy
Neoplasms
Neoplastic Stem Cells
Neuropilins
Receptors, Vascular Endothelial Growth Factor
Signal Transduction
Tumor Microenvironment
Vascular Endothelial Growth Factor A
Cancer Biology
Cells
Neoplasms
Metadata
Show full item recordAbstract
The function of vascular endothelial growth factor (VEGF) in cancer is not limited to angiogenesis and vascular permeability. VEGF-mediated signalling occurs in tumour cells, and this signalling contributes to key aspects of tumorigenesis, including the function of cancer stem cells and tumour initiation. In addition to VEGF receptor tyrosine kinases, the neuropilins are crucial for mediating the effects of VEGF on tumour cells, primarily because of their ability to regulate the function and the trafficking of growth factor receptors and integrins. This has important implications for our understanding of tumour biology and for the development of more effective therapeutic approaches.Source
Nat Rev Cancer. 2013 Dec;13(12):871-82. doi: 10.1038/nrc3627. Link to article on publisher's site
DOI
10.1038/nrc3627Permanent Link to this Item
http://hdl.handle.net/20.500.14038/26302PubMed ID
24263190Related Resources
ae974a485f413a2113503eed53cd6c53
10.1038/nrc3627