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    Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells

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    Authors
    Chen, Junjie
    Silver, Daniel P.
    Walpita, Deepika
    Cantor, Sharon B.
    Gazdar, Adi F.
    Tomlinson, Gail
    Couch, Fergus J.
    Weber, Barbara L.
    Ashley, Terry
    Livingston, David M.
    Scully, Ralph
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    UMass Chan Affiliations
    Department of Cancer Biology
    Document Type
    Journal Article
    Publication Date
    1998-10-17
    Keywords
    Antibodies, Monoclonal
    BRCA1 Protein
    BRCA2 Protein
    Breast Neoplasms
    Cell Line
    Cell Nucleus
    Chromosome Mapping
    DNA Damage
    DNA Repair
    DNA Replication
    DNA-Binding Proteins
    Female
    *Genes, BRCA1
    *Genes, Tumor Suppressor
    Humans
    Meiosis
    Mitosis
    Neoplasm Proteins
    Ovarian Neoplasms
    Rad51 Recombinase
    Transcription Factors
    Transfection
    Tumor Cells, Cultured
    Zygote
    Cancer Biology
    Neoplasms
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    Link to Full Text
    http://dx.doi.org/10.1016/S1097-2765(00)80276-2
    Abstract
    BRCA1 and BRCA2 account for most cases of familial, early onset breast and/or ovarian cancer and encode products that each interact with hRAD51. Results presented here show that BRCA1 and BRCA2 coexist in a biochemical complex and colocalize in subnuclear foci in somatic cells and on the axial elements of developing synaptonemal complexes. Like BRCA1 and RAD51, BRCA2 relocates to PCNA+ replication sites following exposure of S phase cells to hydroxyurea or UV irradiation. Thus, BRCA1 and BRCA2 participate, together, in a pathway(s) associated with the activation of double-strand break repair and/or homologous recombination. Dysfunction of this pathway may be a general phenomenon in the majority of cases of hereditary breast and/or ovarian cancer.
    Source
    Mol Cell. 1998 Sep;2(3):317-28.
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/26308
    PubMed ID
    9774970
    Related Resources
    Link to Article in PubMed
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    UMass Chan Faculty and Researcher Publications

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