Multiple inflammatory biomarkers in relation to cardiovascular events and mortality in the community
dc.contributor.author | Schnabel, Renate B. | |
dc.contributor.author | Yin, Xiaoyan | |
dc.contributor.author | Larson, Martin G. | |
dc.contributor.author | Yamamoto, Jennifer F. | |
dc.contributor.author | Fontes, Joao D. | |
dc.contributor.author | Kathiresan, Sekar | |
dc.contributor.author | Rong, Jian | |
dc.contributor.author | Levy, Daniel | |
dc.contributor.author | Keaney, John F. Jr. | |
dc.contributor.author | Wang, Thomas J. | |
dc.contributor.author | Murabito, Joanne M. | |
dc.contributor.author | Vasan, Ramachandran S. | |
dc.contributor.author | Benjamin, Emelia J. | |
dc.date | 2022-08-11T08:08:02.000 | |
dc.date.accessioned | 2022-08-23T15:40:07Z | |
dc.date.available | 2022-08-23T15:40:07Z | |
dc.date.issued | 2013-07-01 | |
dc.date.submitted | 2018-05-02 | |
dc.identifier.citation | <p>Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1728-33. doi: 10.1161/ATVBAHA.112.301174. Epub 2013 May 2.</p> | |
dc.identifier.issn | 1079-5642 (Linking) | |
dc.identifier.doi | 10.1161/ATVBAHA.112.301174 | |
dc.identifier.pmid | 23640499 | |
dc.identifier.uri | http://hdl.handle.net/20.500.14038/26329 | |
dc.description.abstract | OBJECTIVE: Evidence suggests that chronic low-grade inflammation and oxidative stress are related to cardiovascular disease (CVD) and mortality. APPROACH AND RESULTS: We examined 11 established and novel biomarkers representing inflammation and oxidative stress (C-reactive protein, fibrinogen, interleukin-6, intercellular adhesion molecule-1, lipoprotein-associated phospholipase-A2 [mass and activity], monocyte chemoattractant protein-1, myeloperoxidase, CD40 ligand, P-selectin, and tumor necrosis factor receptor II [TNFRII]) in relation to incident major CVD and mortality in the community. We studied 3035 participants (mean age, 61 +/- 9 years; 53% women). During follow-up (median, 8.9 years), 253 participants experienced a CVD event and 343 died. C-reactive protein (hazard ratio [HR] reported per SD ln-transformed biomarker, 1.18; 95% confidence interval [CI], 1.02-1.35; nominal P=0.02) and TNFRII (HR, 1.15; 95% CI, 1.01-1.32; nominal P=0.04) were retained in multivariable-adjusted models for major CVD, but were not significant after adjustment for multiple testing. The biomarkers related to mortality were TNFRII (HR, 1.33; 95% CI, 1.19-1.49; P < 0.0001), ICAM-1 (HR, 1.24; 95% CI, 1.12-1.37; P < 0.0001), and interleukin-6 (HR, 1.25; 95% CI, 1.12-1.39; P < 0.0001). The addition of these markers to the model, including traditional risk factors, increased discrimination and reclassification for risk of death (P < 0.0001), but not for CVD. CONCLUSIONS: Of 11 inflammatory biomarkers tumor necrosis factor receptor II was related to cardiovascular disease and mortality in the Framingham Heart Study. The combination of TNFRII with C-reactive protein in relation to CVD and with interleukin-6 to mortality increased the predictive ability in addition to CVD risk factors for total mortality but not for incident CVD. | |
dc.language.iso | en_US | |
dc.relation | <p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=23640499&dopt=Abstract">Link to Article in PubMed</a></p> | |
dc.relation.url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753537/ | |
dc.subject | cardiovascular disease | |
dc.subject | cohort | |
dc.subject | epidemiology | |
dc.subject | inflammation | |
dc.subject | mortality | |
dc.subject | Biological Factors | |
dc.subject | Cardiology | |
dc.subject | Cardiovascular Diseases | |
dc.subject | Epidemiology | |
dc.subject | Pathological Conditions, Signs and Symptoms | |
dc.title | Multiple inflammatory biomarkers in relation to cardiovascular events and mortality in the community | |
dc.type | Journal Article | |
dc.source.journaltitle | Arteriosclerosis, thrombosis, and vascular biology | |
dc.source.volume | 33 | |
dc.source.issue | 7 | |
dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/cardio_pp/108 | |
dc.identifier.contextkey | 12057244 | |
html.description.abstract | <p>OBJECTIVE: Evidence suggests that chronic low-grade inflammation and oxidative stress are related to cardiovascular disease (CVD) and mortality.</p> <p>APPROACH AND RESULTS: We examined 11 established and novel biomarkers representing inflammation and oxidative stress (C-reactive protein, fibrinogen, interleukin-6, intercellular adhesion molecule-1, lipoprotein-associated phospholipase-A2 [mass and activity], monocyte chemoattractant protein-1, myeloperoxidase, CD40 ligand, P-selectin, and tumor necrosis factor receptor II [TNFRII]) in relation to incident major CVD and mortality in the community. We studied 3035 participants (mean age, 61 +/- 9 years; 53% women). During follow-up (median, 8.9 years), 253 participants experienced a CVD event and 343 died. C-reactive protein (hazard ratio [HR] reported per SD ln-transformed biomarker, 1.18; 95% confidence interval [CI], 1.02-1.35; nominal P=0.02) and TNFRII (HR, 1.15; 95% CI, 1.01-1.32; nominal P=0.04) were retained in multivariable-adjusted models for major CVD, but were not significant after adjustment for multiple testing. The biomarkers related to mortality were TNFRII (HR, 1.33; 95% CI, 1.19-1.49; P < 0.0001), ICAM-1 (HR, 1.24; 95% CI, 1.12-1.37; P < 0.0001), and interleukin-6 (HR, 1.25; 95% CI, 1.12-1.39; P < 0.0001). The addition of these markers to the model, including traditional risk factors, increased discrimination and reclassification for risk of death (P < 0.0001), but not for CVD.</p> <p>CONCLUSIONS: Of 11 inflammatory biomarkers tumor necrosis factor receptor II was related to cardiovascular disease and mortality in the Framingham Heart Study. The combination of TNFRII with C-reactive protein in relation to CVD and with interleukin-6 to mortality increased the predictive ability in addition to CVD risk factors for total mortality but not for incident CVD.</p> | |
dc.identifier.submissionpath | cardio_pp/108 | |
dc.contributor.department | Department of Medicine, Division of Cardiovascular Medicine | |
dc.source.pages | 1728-33 |