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dc.contributor.authorSchnabel, Renate B.
dc.contributor.authorYin, Xiaoyan
dc.contributor.authorLarson, Martin G.
dc.contributor.authorYamamoto, Jennifer F.
dc.contributor.authorFontes, Joao D.
dc.contributor.authorKathiresan, Sekar
dc.contributor.authorRong, Jian
dc.contributor.authorLevy, Daniel
dc.contributor.authorKeaney, John F. Jr.
dc.contributor.authorWang, Thomas J.
dc.contributor.authorMurabito, Joanne M.
dc.contributor.authorVasan, Ramachandran S.
dc.contributor.authorBenjamin, Emelia J.
dc.date2022-08-11T08:08:02.000
dc.date.accessioned2022-08-23T15:40:07Z
dc.date.available2022-08-23T15:40:07Z
dc.date.issued2013-07-01
dc.date.submitted2018-05-02
dc.identifier.citation<p>Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1728-33. doi: 10.1161/ATVBAHA.112.301174. Epub 2013 May 2.</p>
dc.identifier.issn1079-5642 (Linking)
dc.identifier.doi10.1161/ATVBAHA.112.301174
dc.identifier.pmid23640499
dc.identifier.urihttp://hdl.handle.net/20.500.14038/26329
dc.description.abstractOBJECTIVE: Evidence suggests that chronic low-grade inflammation and oxidative stress are related to cardiovascular disease (CVD) and mortality. APPROACH AND RESULTS: We examined 11 established and novel biomarkers representing inflammation and oxidative stress (C-reactive protein, fibrinogen, interleukin-6, intercellular adhesion molecule-1, lipoprotein-associated phospholipase-A2 [mass and activity], monocyte chemoattractant protein-1, myeloperoxidase, CD40 ligand, P-selectin, and tumor necrosis factor receptor II [TNFRII]) in relation to incident major CVD and mortality in the community. We studied 3035 participants (mean age, 61 +/- 9 years; 53% women). During follow-up (median, 8.9 years), 253 participants experienced a CVD event and 343 died. C-reactive protein (hazard ratio [HR] reported per SD ln-transformed biomarker, 1.18; 95% confidence interval [CI], 1.02-1.35; nominal P=0.02) and TNFRII (HR, 1.15; 95% CI, 1.01-1.32; nominal P=0.04) were retained in multivariable-adjusted models for major CVD, but were not significant after adjustment for multiple testing. The biomarkers related to mortality were TNFRII (HR, 1.33; 95% CI, 1.19-1.49; P < 0.0001), ICAM-1 (HR, 1.24; 95% CI, 1.12-1.37; P < 0.0001), and interleukin-6 (HR, 1.25; 95% CI, 1.12-1.39; P < 0.0001). The addition of these markers to the model, including traditional risk factors, increased discrimination and reclassification for risk of death (P < 0.0001), but not for CVD. CONCLUSIONS: Of 11 inflammatory biomarkers tumor necrosis factor receptor II was related to cardiovascular disease and mortality in the Framingham Heart Study. The combination of TNFRII with C-reactive protein in relation to CVD and with interleukin-6 to mortality increased the predictive ability in addition to CVD risk factors for total mortality but not for incident CVD.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=23640499&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753537/
dc.subjectcardiovascular disease
dc.subjectcohort
dc.subjectepidemiology
dc.subjectinflammation
dc.subjectmortality
dc.subjectBiological Factors
dc.subjectCardiology
dc.subjectCardiovascular Diseases
dc.subjectEpidemiology
dc.subjectPathological Conditions, Signs and Symptoms
dc.titleMultiple inflammatory biomarkers in relation to cardiovascular events and mortality in the community
dc.typeJournal Article
dc.source.journaltitleArteriosclerosis, thrombosis, and vascular biology
dc.source.volume33
dc.source.issue7
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/cardio_pp/108
dc.identifier.contextkey12057244
html.description.abstract<p>OBJECTIVE: Evidence suggests that chronic low-grade inflammation and oxidative stress are related to cardiovascular disease (CVD) and mortality.</p> <p>APPROACH AND RESULTS: We examined 11 established and novel biomarkers representing inflammation and oxidative stress (C-reactive protein, fibrinogen, interleukin-6, intercellular adhesion molecule-1, lipoprotein-associated phospholipase-A2 [mass and activity], monocyte chemoattractant protein-1, myeloperoxidase, CD40 ligand, P-selectin, and tumor necrosis factor receptor II [TNFRII]) in relation to incident major CVD and mortality in the community. We studied 3035 participants (mean age, 61 +/- 9 years; 53% women). During follow-up (median, 8.9 years), 253 participants experienced a CVD event and 343 died. C-reactive protein (hazard ratio [HR] reported per SD ln-transformed biomarker, 1.18; 95% confidence interval [CI], 1.02-1.35; nominal P=0.02) and TNFRII (HR, 1.15; 95% CI, 1.01-1.32; nominal P=0.04) were retained in multivariable-adjusted models for major CVD, but were not significant after adjustment for multiple testing. The biomarkers related to mortality were TNFRII (HR, 1.33; 95% CI, 1.19-1.49; P < 0.0001), ICAM-1 (HR, 1.24; 95% CI, 1.12-1.37; P < 0.0001), and interleukin-6 (HR, 1.25; 95% CI, 1.12-1.39; P < 0.0001). The addition of these markers to the model, including traditional risk factors, increased discrimination and reclassification for risk of death (P < 0.0001), but not for CVD.</p> <p>CONCLUSIONS: Of 11 inflammatory biomarkers tumor necrosis factor receptor II was related to cardiovascular disease and mortality in the Framingham Heart Study. The combination of TNFRII with C-reactive protein in relation to CVD and with interleukin-6 to mortality increased the predictive ability in addition to CVD risk factors for total mortality but not for incident CVD.</p>
dc.identifier.submissionpathcardio_pp/108
dc.contributor.departmentDepartment of Medicine, Division of Cardiovascular Medicine
dc.source.pages1728-33


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