Body mass index, but not physical activity, is associated with C-reactive protein
Authors
Rawson, Eric S.Freedson, Patty S.
Osganian, Stavroula K.
Matthews, Charles E.
Reed, George W.
Ockene, Ira S.
UMass Chan Affiliations
Department of Medicine, Division of Cardiovascular MedicineDepartment of Medicine, Division of Preventive and Behavioral Medicine
Document Type
Journal ArticlePublication Date
2003-07-04Keywords
AdultBiological Markers
*Body Mass Index
C-Reactive Protein
Exercise
Female
Heart Diseases
Humans
Inflammation
Longitudinal Studies
Male
Middle Aged
Obesity
*Physical Fitness
Risk Factors
Cardiology
Cardiovascular Diseases
Metadata
Show full item recordAbstract
Elevated high-sensitivity c-reactive protein (hs-CRP) is associated with increased risk of future first and recurrent coronary events and has been associated with both high body mass index (BMI) and low physical activity in cross sectional studies. PURPOSE: To longitudinally examine the effects of BMI and both current and previous-year physical activity on hs-CRP in healthy men and women (N = 109). METHODS: BMI and hs-CRP were measured five times (baseline and quarterly) over 1 yr. Current physical activity was assessed 12-15 times during the study via 24-h recall. Previous-year physical activity was assessed using the Baecke questionnaire at baseline. RESULTS: Mean BMI and hs-CRP were unchanged over the course of the study, but current physical activity increased on visit 3. Average hs-CRP was not related to average current physical activity or to natural changes in current physical activity across the five visits. Additionally, current physical activity on any given visit was not associated with hs-CRP on the following visit. When current physical activity, BMI, age, gender, and smoking were included in the statistical model, only BMI was significantly related to hs-CRP (P < 0.001). Average hs-CRP was significantly correlated with average BMI (r = 0.50; P < 0.001) but was not related to previous-year (Baecke) physical activity levels (r = 0.02; P = 0.89). When subjects were grouped by BMI (<25 kg.m-2, 25-29.9 kg x m-2, >30 kg x m-2) hs-CRP was significantly greater in obese (3.2 +/- 1.9 mg.L-1) and overweight (2.1 +/- 1.7 mg x L-1) than normal weight (1.1 +/- 1.0 mg.L-1) subjects (ANOVA P < 0.05). Current physical activity was similar between the three BMI groups at all times, and was unrelated to hs-CRP in all groups, throughout the study period. CONCLUSION: These data indicate that BMI, but not previous-year or current physical activity, predicts hs-CRP.Source
Med Sci Sports Exerc. 2003 Jul;35(7):1160-6. Link to article on publisher's siteDOI
10.1249/01.MSS.0000074565.79230.ABPermanent Link to this Item
http://hdl.handle.net/20.500.14038/26336PubMed ID
12840637Related Resources
Link to article in PubMedae974a485f413a2113503eed53cd6c53
10.1249/01.MSS.0000074565.79230.AB