Vitamin D intake from foods and supplements and depressive symptoms in a diverse Population of Older Women.
Authors
Bertone-Johnson, ElizabethPowers, Sally I.
Spangler, Leslie
Brunner, Robert L.
Michael, Yvonne L.
Larson, Joseph C.
Millen, Amy E.
Bueche, Maria N.
Salmoirago Blotcher, Elena
Liu, Simin
Wassertheil-Smoller, Sylvia
Ockene, Judith K.
Ockene, Ira S.
Manson, JoAnn E.
UMass Chan Affiliations
Department of Medicine, Division of Preventive and Behavioral MedicineDepartment of Medicine, Division of Cardiovascular Medicine
Document Type
Journal ArticlePublication Date
2011-08-24Keywords
Vitamin DDepression
Postmenopause
Women
physical activity
antidepressive agents
depressive disorders
food
vitamin d
elderly
Cardiology
Cardiovascular Diseases
Dietetics and Clinical Nutrition
Epidemiology
Geriatrics
Mental Disorders
Musculoskeletal, Neural, and Ocular Physiology
Polycyclic Compounds
Reproductive and Urinary Physiology
Therapeutics
Women's Health
Metadata
Show full item recordAbstract
BACKGROUND: Vitamin D may plausibly reduce the occurrence of depression in postmenopausal women; however, epidemiologic evidence is limited, and few prospective studies have been conducted. OBJECTIVE: We conducted a cross-sectional and prospective analysis of vitamin D intake from foods and supplements and risk of depressive symptoms. DESIGN: Study participants were 81,189 members of the Women's Health Initiative (WHI) Observational Study who were aged 50-79 y at baseline. Vitamin D intake at baseline was measured by food-frequency and supplement-use questionnaires. Depressive symptoms at baseline and after 3 y were assessed by using the Burnam scale and current antidepressant medication use. RESULTS: After age, physical activity, and other factors were controlled for, women who reported a total intake of ≥800 IU vitamin D/d had a prevalence OR for depressive symptoms of 0.79 (95% CI: 0.71, 0.89; P-trend < 0.001) compared with women who reported a total intake of CONCLUSIONS: Overall, our findings support a potential inverse association of vitamin D, primarily from food sources, and depressive symptoms in postmenopausal women. Additional prospective studies and randomized trials are essential in establishing whether the improvement of vitamin D status holds promise for the prevention of depression, the treatment of depression, or both.Source
American Journal of Clinical Nutrition. 2011 Aug 24, doi: 10.3945/ajcn.111.017384. To be published in the October 2011 issue of American Journal of Clinical Nutrition.
DOI
10.3945/ajcn.111.017384Permanent Link to this Item
http://hdl.handle.net/20.500.14038/26398PubMed ID
21865327Related Resources
ae974a485f413a2113503eed53cd6c53
10.3945/ajcn.111.017384