Vitamin D intake from foods and supplements and depressive symptoms in a diverse Population of Older Women.
Powers, Sally I.
Brunner, Robert L.
Michael, Yvonne L.
Larson, Joseph C.
Millen, Amy E.
Bueche, Maria N.
Salmoirago Blotcher, Elena
Ockene, Judith K.
Ockene, Ira S.
Manson, JoAnn E.
UMass Chan AffiliationsDepartment of Medicine, Division of Preventive and Behavioral Medicine
Department of Medicine, Division of Cardiovascular Medicine
Document TypeJournal Article
Dietetics and Clinical Nutrition
Musculoskeletal, Neural, and Ocular Physiology
Reproductive and Urinary Physiology
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AbstractBACKGROUND: Vitamin D may plausibly reduce the occurrence of depression in postmenopausal women; however, epidemiologic evidence is limited, and few prospective studies have been conducted. OBJECTIVE: We conducted a cross-sectional and prospective analysis of vitamin D intake from foods and supplements and risk of depressive symptoms. DESIGN: Study participants were 81,189 members of the Women's Health Initiative (WHI) Observational Study who were aged 50-79 y at baseline. Vitamin D intake at baseline was measured by food-frequency and supplement-use questionnaires. Depressive symptoms at baseline and after 3 y were assessed by using the Burnam scale and current antidepressant medication use. RESULTS: After age, physical activity, and other factors were controlled for, women who reported a total intake of ≥800 IU vitamin D/d had a prevalence OR for depressive symptoms of 0.79 (95% CI: 0.71, 0.89; P-trend < 0.001) compared with women who reported a total intake of CONCLUSIONS: Overall, our findings support a potential inverse association of vitamin D, primarily from food sources, and depressive symptoms in postmenopausal women. Additional prospective studies and randomized trials are essential in establishing whether the improvement of vitamin D status holds promise for the prevention of depression, the treatment of depression, or both.
American Journal of Clinical Nutrition. 2011 Aug 24, doi: 10.3945/ajcn.111.017384. To be published in the October 2011 issue of American Journal of Clinical Nutrition.
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/26398