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    Vitamin D intake from foods and supplements and depressive symptoms in a diverse Population of Older Women.

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    Authors
    Bertone-Johnson, Elizabeth
    Powers, Sally I.
    Spangler, Leslie
    Brunner, Robert L.
    Michael, Yvonne L.
    Larson, Joseph C.
    Millen, Amy E.
    Bueche, Maria N.
    Salmoirago Blotcher, Elena
    Liu, Simin
    Wassertheil-Smoller, Sylvia
    Ockene, Judith K.
    Ockene, Ira S.
    Manson, JoAnn E.
    Show allShow less
    UMass Chan Affiliations
    Department of Medicine, Division of Preventive and Behavioral Medicine
    Department of Medicine, Division of Cardiovascular Medicine
    Document Type
    Journal Article
    Publication Date
    2011-08-24
    Keywords
    Vitamin D
    Depression
    Postmenopause
    Women
    physical activity
    antidepressive agents
    depressive disorders
    food
    vitamin d
    elderly
    Cardiology
    Cardiovascular Diseases
    Dietetics and Clinical Nutrition
    Epidemiology
    Geriatrics
    Mental Disorders
    Musculoskeletal, Neural, and Ocular Physiology
    Polycyclic Compounds
    Reproductive and Urinary Physiology
    Therapeutics
    Women's Health
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    Link to Full Text
    https://doi.org/10.3945/ajcn.111.017384
    Abstract
    BACKGROUND: Vitamin D may plausibly reduce the occurrence of depression in postmenopausal women; however, epidemiologic evidence is limited, and few prospective studies have been conducted. OBJECTIVE: We conducted a cross-sectional and prospective analysis of vitamin D intake from foods and supplements and risk of depressive symptoms. DESIGN: Study participants were 81,189 members of the Women's Health Initiative (WHI) Observational Study who were aged 50-79 y at baseline. Vitamin D intake at baseline was measured by food-frequency and supplement-use questionnaires. Depressive symptoms at baseline and after 3 y were assessed by using the Burnam scale and current antidepressant medication use. RESULTS: After age, physical activity, and other factors were controlled for, women who reported a total intake of ≥800 IU vitamin D/d had a prevalence OR for depressive symptoms of 0.79 (95% CI: 0.71, 0.89; P-trend < 0.001) compared with women who reported a total intake of CONCLUSIONS: Overall, our findings support a potential inverse association of vitamin D, primarily from food sources, and depressive symptoms in postmenopausal women. Additional prospective studies and randomized trials are essential in establishing whether the improvement of vitamin D status holds promise for the prevention of depression, the treatment of depression, or both.
    Source

    American Journal of Clinical Nutrition. 2011 Aug 24, doi: 10.3945/ajcn.111.017384. To be published in the October 2011 issue of American Journal of Clinical Nutrition.

    DOI
    10.3945/ajcn.111.017384
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/26398
    PubMed ID
    21865327
    Related Resources

    Link to article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.3945/ajcn.111.017384
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