The Simple Arithmetic of Mixed Aortic Valve Disease: LVH + Volume Load = Trouble
UMass Chan AffiliationsDivision of Cardiovascular Medicine, Department of Medicine
mixed aortic valve disease
MetadataShow full item record
AbstractAortic stenosis (AS) is the prototypical pressure overload lesion. The Gunther-Grossman paradigm of the 1970s dictates that as afterload increases, concentric hypertrophy—increases in left ventricular (LV) mass index and relative wall thickness—normalize systolic load and allow for normal ejection fraction despite markedly increased intraventricular systolic pressure. In some individuals, this compensatory process appears to be excessive and can be associated with poor outcome even with aortic valve replacement (AVR). Increasingly, attention has been focused on the malefic consequences for diastolic function of such ‘compensatory’ hypertrophy.
J Am Coll Cardiol. 2016 May 24;67(20):2330-2333. doi: 10.1016/j.jacc.2016.03.549. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/26415