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    One to only two: a short history of the centrosome and its duplication

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    Authors
    Sluder, Greenfield
    UMass Chan Affiliations
    Department of Cell and Developmental Biology
    Document Type
    Journal Article
    Publication Date
    2014-09-05
    Keywords
    Animals
    Cell Division
    Centrioles
    Centrosome
    *Models, Biological
    Sea Urchins
    Species Specificity
    Spindle Apparatus
    centriole; centrosome; duplication; template
    Cell and Developmental Biology
    Cell Biology
    Cellular and Molecular Physiology
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    Link to Full Text
    http://dx.doi.org/10.1098/rstb.2013.0455
    Abstract
    This review discusses some of the history of the fundamental, but not fully solved problem of how the centrosome duplicates from one to only two as the cell prepares for mitosis. We start with some of the early descriptions of the centrosome and the remarkably prescient but then controversial inferences drawn concerning its function in the cell. For more than 100 years, one of the most difficult issues for the concept of the centrosome has been to integrate observations that centrosomes appear to be important for spindle assembly in animal cells yet are not evident in higher plant cells and some animal cells. This stirred debate over the existence of centrosomes and their importance. A parallel debate concerned the role of the centrioles in organizing centrosomes. The relatively recent elucidation of bipolar spindle assembly around chromatin allows a re-examination of the role of centrioles in controlling centrosome duplication in animal cells. The problem of how centrosomes precisely double in preparation for mitosis in animal cells has now moved to the mystery of how only one procentriole is assembled at each mother centriole.
    Source
    Philos Trans R Soc Lond B Biol Sci. 2014 Sep 5;369(1650). pii: 20130455. doi: 1098/rstb.2013.0455. Link to article on publisher's site
    DOI
    1098/rstb.2013.0455
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/26462
    PubMed ID
    25047609
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    1098/rstb.2013.0455
    Scopus Count
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    UMass Chan Faculty and Researcher Publications

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