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    Extra-embryonic Wnt3 regulates the establishment of the primitive streak in mice

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    Authors
    Yoon, Yeonsoo
    Huang, Tingting
    Tortelote, Giovane G.
    Wakamiya, Maki
    Hadjantonakis, Anna-Katerina
    Behringer, Richard R.
    Rivera-Perez, Jaime A.
    UMass Chan Affiliations
    Rivera Lab
    Department of Cell and Developmental Biology
    Document Type
    Journal Article
    Publication Date
    2015-07-01
    Keywords
    Animals
    Body Patterning
    Endoderm
    Gastrulation
    Gene Expression Regulation, Developmental
    Mice
    Primitive Streak
    Wnt3 Protein
    Axial specification
    Embryo
    Gastrulation
    Mouse
    Primitive streak
    Wnt3
    Cell Biology
    Developmental Biology
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    Link to Full Text
    http://dx.doi.org/10.1016/j.ydbio.2015.04.008
    Abstract
    The establishment of the head to tail axis at early stages of development is a fundamental aspect of vertebrate embryogenesis. In mice, experimental embryology, genetics and expression studies have suggested that the visceral endoderm, an extra-embryonic tissue, plays an important role in anteroposterior axial development. Here we show that absence of Wnt3 in the posterior visceral endoderm leads to delayed formation of the primitive streak and that interplay between anterior and posterior visceral endoderm restricts the position of the primitive streak. Embryos lacking Wnt3 in the visceral endoderm, however, appear normal by E9.5. Our results suggest a model for axial development in which multiple signals are required for anteroposterior axial development in mammals.
    Source

    Dev Biol. 2015 Jul 1;403(1):80-8. doi: 10.1016/j.ydbio.2015.04.008. Link to article on publisher's site.

    DOI
    10.1016/j.ydbio.2015.04.008
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/26482
    PubMed ID
    25907228
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    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ydbio.2015.04.008
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