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    Prepubertal Serum Concentrations of Organochlorine Pesticides and Age at Sexual Maturity in Russian Boys

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    Authors
    Lam, Thuy
    Williams, Paige L.
    Lee, Mary M.
    Korrick, Susan A.
    Birnbaum, Linda S.
    Burns, Jane S.
    Sergeyev, Oleg
    Revich, Boris
    Altshul, Larisa M.
    Patterson, Donald G. Jr
    Hauser, Russ
    Show allShow less
    UMass Chan Affiliations
    Department of Cell and Developmental Biology
    Department of Pediatrics
    Document Type
    Journal Article
    Publication Date
    2015-05-22
    Keywords
    Cell and Developmental Biology
    Endocrinology
    Endocrinology, Diabetes, and Metabolism
    Environmental Public Health
    Medical Toxicology
    Pediatrics
    Reproductive and Urinary Physiology
    
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    Abstract
    BACKGROUND: Few human studies have evaluated the impact of childhood exposure to organochlorine pesticides (OCP) on pubertal development. OBJECTIVE: To evaluate associations of serum OCP concentrations [hexachlorobenzene (HCB), beta-hexachlorocyclohexane (beta-HCH), and p,p-dichlorodiphenyldichloroethylene (p,p'-DDE)] with age at attainment of sexual maturity among boys. METHODS: From 2003-2005, 350 8-9 year-old boys from Chapaevsk, Russia with measured OCPs were enrolled and followed annually for eight years. We used multivariable interval-censored models to evaluate associations of OCPs (quartiles) with three physician-assessed measures of sexual maturity: Tanner stage 5 for genitalia growth, Tanner stage 5 for pubic hair growth, or testicular volume (TV) > /=20 mL in either testis. RESULTS: In adjusted models, boys with higher HCB concentrations achieved sexual maturity reflected by TV > /=20 mL a mean of 3.1 months (95% CI: -1.7, 7.8), 5.3 months (95% CI: 0.6, 10.1), and 5.0 months (95% CI: 0.2, 9.8) later for quartiles Q2, Q3, and Q4, respectively compared to Q1 (trend p=0.04). Tanner stage 5 for genitalia growth was attained a mean of 2.2 months (95% CI: -3.1, 7.5), 5.7 months (95% CI: 0.4, 11.0), and 3.7 months (-1.7, 9.1) later for quartiles Q2, Q3, and Q4 respectively of beta-HCH as compared to Q1 (trend p=0.09). Tanner stage 5 for pubic hair growth occurred 6-9 months later on average for boys in the highest vs. lowest quartile for HCB (trend p < 0.001), beta-HCH (trend p=0.01), and p,p'-DDE (trend p=0.04). No associations were observed between p,p'-DDE and Tanner stage 5 for genitalia growth or TV > /=20 mL. CONCLUSIONS AND RELEVANCE: Higher prepubertal serum HCB and beta-HCH concentrations were associated with a later age at attainment of sexual maturity. Only the highest quartile of serum p,p'-DDE was associated with later pubic hair maturation.
    Source
    Lam T, Williams PL, Lee MM, Korrick SA, Birnbaum LS, Burns JS, Sergeyev O, Revich B, Altshul LM, Patterson DG Jr, Hauser R. Prepubertal Serum Concentrations of Organochlorine Pesticides and Age at Sexual Maturity in Russian Boys. Environ Health Perspect; http://dx.doi.org/10.1289/ehp.1409022. Link to article on publisher's site.
    DOI
    10.1289/ehp.1409022
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/26488
    PubMed ID
    26009253
    Related Resources
    Link to Article in PubMed
    Rights

    EHP is a publication of the U.S. Government. Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged .

    ae974a485f413a2113503eed53cd6c53
    10.1289/ehp.1409022
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