Prepubertal Serum Concentrations of Organochlorine Pesticides and Age at Sexual Maturity in Russian Boys
Authors
Lam, ThuyWilliams, Paige L.
Lee, Mary M.
Korrick, Susan A.
Birnbaum, Linda S.
Burns, Jane S.
Sergeyev, Oleg
Revich, Boris
Altshul, Larisa M.
Patterson, Donald G. Jr
Hauser, Russ
Document Type
Journal ArticlePublication Date
2015-05-22Keywords
Cell and Developmental BiologyEndocrinology
Endocrinology, Diabetes, and Metabolism
Environmental Public Health
Medical Toxicology
Pediatrics
Reproductive and Urinary Physiology
Metadata
Show full item recordAbstract
BACKGROUND: Few human studies have evaluated the impact of childhood exposure to organochlorine pesticides (OCP) on pubertal development. OBJECTIVE: To evaluate associations of serum OCP concentrations [hexachlorobenzene (HCB), beta-hexachlorocyclohexane (beta-HCH), and p,p-dichlorodiphenyldichloroethylene (p,p'-DDE)] with age at attainment of sexual maturity among boys. METHODS: From 2003-2005, 350 8-9 year-old boys from Chapaevsk, Russia with measured OCPs were enrolled and followed annually for eight years. We used multivariable interval-censored models to evaluate associations of OCPs (quartiles) with three physician-assessed measures of sexual maturity: Tanner stage 5 for genitalia growth, Tanner stage 5 for pubic hair growth, or testicular volume (TV) > /=20 mL in either testis. RESULTS: In adjusted models, boys with higher HCB concentrations achieved sexual maturity reflected by TV > /=20 mL a mean of 3.1 months (95% CI: -1.7, 7.8), 5.3 months (95% CI: 0.6, 10.1), and 5.0 months (95% CI: 0.2, 9.8) later for quartiles Q2, Q3, and Q4, respectively compared to Q1 (trend p=0.04). Tanner stage 5 for genitalia growth was attained a mean of 2.2 months (95% CI: -3.1, 7.5), 5.7 months (95% CI: 0.4, 11.0), and 3.7 months (-1.7, 9.1) later for quartiles Q2, Q3, and Q4 respectively of beta-HCH as compared to Q1 (trend p=0.09). Tanner stage 5 for pubic hair growth occurred 6-9 months later on average for boys in the highest vs. lowest quartile for HCB (trend p < 0.001), beta-HCH (trend p=0.01), and p,p'-DDE (trend p=0.04). No associations were observed between p,p'-DDE and Tanner stage 5 for genitalia growth or TV > /=20 mL. CONCLUSIONS AND RELEVANCE: Higher prepubertal serum HCB and beta-HCH concentrations were associated with a later age at attainment of sexual maturity. Only the highest quartile of serum p,p'-DDE was associated with later pubic hair maturation.Source
Lam T, Williams PL, Lee MM, Korrick SA, Birnbaum LS, Burns JS, Sergeyev O, Revich B, Altshul LM, Patterson DG Jr, Hauser R. Prepubertal Serum Concentrations of Organochlorine Pesticides and Age at Sexual Maturity in Russian Boys. Environ Health Perspect; http://dx.doi.org/10.1289/ehp.1409022. Link to article on publisher's site.DOI
10.1289/ehp.1409022Permanent Link to this Item
http://hdl.handle.net/20.500.14038/26488PubMed ID
26009253Related Resources
Link to Article in PubMedRights
EHP is a publication of the U.S. Government. Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged .
ae974a485f413a2113503eed53cd6c53
10.1289/ehp.1409022