An invertebrate smooth muscle with striated muscle myosin filaments
UMass Chan Affiliations
Department of Cell and Developmental BiologyDocument Type
Journal ArticlePublication Date
2015-10-20Keywords
Amino Acid SequenceAnimals
Microscopy, Electron
Molecular Sequence Data
Muscle, Smooth
Myosins
Phylogeny
Schistosoma mansoni
Sequence Homology, Amino Acid
Schistosoma mansonimuscle contractionmuscle structureschistosomethick filamentBiophysicsCell Biology
Metadata
Show full item recordAbstract
Muscle tissues are classically divided into two major types, depending on the presence or absence of striations. In striated muscles, the actin filaments are anchored at Z-lines and the myosin and actin filaments are in register, whereas in smooth muscles, the actin filaments are attached to dense bodies and the myosin and actin filaments are out of register. The structure of the filaments in smooth muscles is also different from that in striated muscles. Here we have studied the structure of myosin filaments from the smooth muscles of the human parasite Schistosoma mansoni. We find, surprisingly, that they are indistinguishable from those in an arthropod striated muscle. This structural similarity is supported by sequence comparison between the schistosome myosin II heavy chain and known striated muscle myosins. In contrast, the actin filaments of schistosomes are similar to those of smooth muscles, lacking troponin-dependent regulation. We conclude that schistosome muscles are hybrids, containing striated muscle-like myosin filaments and smooth muscle-like actin filaments in a smooth muscle architecture. This surprising finding has broad significance for understanding how muscles are built and how they evolved, and challenges the paradigm that smooth and striated muscles always have distinctly different components.Source
Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):E5660-8. doi: 10.1073/pnas.1513439112. Epub 2015 Oct 6. Link to article on publisher's site.DOI
10.1073/pnas.1513439112Permanent Link to this Item
http://hdl.handle.net/20.500.14038/26505PubMed ID
26443857Related Resources
Link to Article in PubMedRights
Publisher PDF posted as allowed by the publisher's author rights policy at http://www.pnas.org/site/aboutpnas/rightpermfaq.xhtml.Scopus Count
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