YY1 Regulates the Germinal Center Reaction by Inhibiting Apoptosis
UMass Chan Affiliations
Department of Microbiology and Physiological SystemsDepartment of Cell and Developmental Biology
Document Type
Journal ArticlePublication Date
2016-09-01
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Show full item recordAbstract
The germinal center (GC) reaction produces high-affinity Abs for a robust adaptive immune response. When dysregulated, the same processes cause GC B cells to become susceptible to lymphomagenesis. It is important to understand how the GC reaction is regulated. In this study, we show that transcription factor YY1 is required to maintain a robust GC reaction in mice. Selective ablation of YY1 significantly decreased in the frequency and number of GC B cells during the GC reaction. This decrease of GC B cells was accompanied by increased apoptosis in these cells. Furthermore, we found that loss of YY1 disrupted the balance between dark zones and light zones, leading to a preferential decrease in dark zone cells. Collectively, these results indicate that YY1 plays an important role in regulating the balance between dark zone and light zone cells in GCs and between survival and death of GC B cells.Source
J Immunol. 2016 Sep 1;197(5):1699-707. doi: 10.4049/jimmunol.1600721. Epub 2016 Jul 22. Link to article on publisher's siteDOI
10.4049/jimmunol.1600721Permanent Link to this Item
http://hdl.handle.net/20.500.14038/26507PubMed ID
27448584Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.4049/jimmunol.1600721