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    The vertebrate primary cilium is a sensory organelle

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    Authors
    Pazour, Gregory J.
    Witman, George B.
    UMass Chan Affiliations
    Program in Molecular Medicine
    Department of Cell Biology
    Document Type
    Journal Article
    Publication Date
    2003-01-09
    Keywords
    Animals
    Calcium Channels
    Cell Membrane
    Cilia
    Eukaryotic Cells
    Humans
    Kidney
    Membrane Proteins
    Receptors, Cell Surface
    Signal Transduction
    TRPP Cation Channels
    Cell Biology
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    Link to Full Text
    http://dx.doi.org/10.1016/S0955-0674(02)00012-1
    Abstract
    The primary cilium is a generally non-motile cilium that occurs singly on most cells in the vertebrate body. The function of this organelle, which has been the subject of much speculation but little experimentation, has been unknown. Recent findings reveal that the primary cilium is an antenna displaying specific receptors and relaying signals from these receptors to the cell body. For example, kidney primary cilia display polycystin-2, which forms part of a Ca2+ channel that initiates a signal that controls cell differentiation and proliferation. Kidney primary cilia also are mechanosensors that, when bent, initiate a Ca2+ signal that spreads throughout the cell and to neighboring cells. Primary cilia on other cell types specifically display different receptors, including those for somatostatin and serotonin.
    Source
    Curr Opin Cell Biol. 2003 Feb;15(1):105-10.
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/26526
    PubMed ID
    12517711
    Related Resources
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    UMass Chan Faculty and Researcher Publications
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