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Transcription-factor-mediated epigenetic control of cell fate and lineage commitment

dc.contributor.authorStein, Gary S.
dc.contributor.authorZaidi, Sayyed K.
dc.contributor.authorStein, Janet L.
dc.contributor.authorLian, Jane B.
dc.contributor.authorVan Wijnen, Andre J.
dc.contributor.authorMontecino, Martin A.
dc.contributor.authorYoung, Daniel W.
dc.contributor.authorJaved, Amjad
dc.contributor.authorPratap, Jitesh
dc.contributor.authorChoi, Je-Yong
dc.contributor.authorAli, Syed A.
dc.contributor.authorPande, Sandhya
dc.contributor.authorHassan, Mohammad Q.
dc.date2022-08-11T08:08:04.000
dc.date.accessioned2022-08-23T15:41:13Z
dc.date.available2022-08-23T15:41:13Z
dc.date.issued2009-02-24
dc.date.submitted2009-11-04
dc.identifier.citationBiochem Cell Biol. 2009 Feb;87(1):1-6. <a href="http://dx.doi.org/10.1139/o08-094">Link to article on publisher's site</a>
dc.identifier.issn0829-8211 (Print)
dc.identifier.doi10.1139/o08-094
dc.identifier.pmid19234518
dc.identifier.urihttp://hdl.handle.net/20.500.14038/26582
dc.description.abstractEpigenetic control is required to maintain competency for the activation and suppression of genes during cell division. The association between regulatory proteins and target gene loci during mitosis is a parameter of the epigenetic control that sustains the transcriptional regulatory machinery that perpetuates gene-expression signatures in progeny cells. The mitotic retention of phenotypic regulatory factors with cell cycle, cell fate, and tissue-specific genes supports the coordinated control that governs the proliferation and differentiation of cell fate and lineage commitment.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=19234518&dopt=Abstract">Link to Article in PubMed</a>
dc.rightsCopyright NRC Research Press.
dc.subjectAnimals
dc.subjectCell Lineage
dc.subjectCell Nucleus
dc.subjectCell Proliferation
dc.subject*Epigenesis, Genetic
dc.subjectHumans
dc.subjectMitosis
dc.subjectTranscription Factors
dc.subjectCell Biology
dc.titleTranscription-factor-mediated epigenetic control of cell fate and lineage commitment
dc.typeJournal Article
dc.source.journaltitleBiochemistry and cell biology = Biochimie et biologie cellulaire
dc.source.volume87
dc.source.issue1
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1088&amp;context=cellbiology_pp&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/cellbiology_pp/89
dc.identifier.contextkey1055018
refterms.dateFOA2022-08-23T15:41:13Z
html.description.abstract<p>Epigenetic control is required to maintain competency for the activation and suppression of genes during cell division. The association between regulatory proteins and target gene loci during mitosis is a parameter of the epigenetic control that sustains the transcriptional regulatory machinery that perpetuates gene-expression signatures in progeny cells. The mitotic retention of phenotypic regulatory factors with cell cycle, cell fate, and tissue-specific genes supports the coordinated control that governs the proliferation and differentiation of cell fate and lineage commitment.</p>
dc.identifier.submissionpathcellbiology_pp/89
dc.contributor.departmentDepartment of Cell Biology
dc.source.pages1-6


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