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dc.contributor.authorZaidi, Sayyed K.
dc.contributor.authorYoung, Daniel W.
dc.contributor.authorMontecino, Martin A.
dc.contributor.authorLian, Jane B.
dc.contributor.authorVan Wijnen, Andre J.
dc.contributor.authorStein, Janet L.
dc.contributor.authorStein, Gary S.
dc.date2022-08-11T08:08:04.000
dc.date.accessioned2022-08-23T15:41:13Z
dc.date.available2022-08-23T15:41:13Z
dc.date.issued2010-07-16
dc.date.submitted2010-08-03
dc.identifier.citationNat Rev Genet. 2010 Aug;11(8):583-9. Epub 2010 Jul 13. <a href="http://dx.doi.org/10.1038/nrg2827">Link to article on publisher's site</a>
dc.identifier.issn1471-0056 (Linking)
dc.identifier.doi10.1038/nrg2827
dc.identifier.pmid20628351
dc.identifier.urihttp://hdl.handle.net/20.500.14038/26584
dc.description.abstractRegulatory machinery is focally organized in the interphase nucleus. The information contained in these focal nuclear microenvironments must be inherited during cell division to sustain physiologically responsive gene expression in progeny cells. Recent results suggest that focal mitotic retention of phenotypic transcription factors at promoters together with histone modifications and DNA methylation--a mechanism collectively known as gene bookmarking--is a novel parameter of inherited epigenetic control that sustains cellular identity after mitosis. The epigenetic signatures imposed by bookmarking poise genes for activation or suppression following mitosis. We discuss the implications of phenotypic transcription factor retention on mitotic chromosomes in biological control and disease.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=20628351&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1038/nrg2827
dc.subjectEpigenesis, Genetic
dc.subjectMitosis
dc.subjectPhenotype
dc.subjectTranscription Factors
dc.subjectHistones
dc.subjectDNA Methylation
dc.subjectCell Biology
dc.titleMitotic bookmarking of genes: a novel dimension to epigenetic control
dc.typeJournal Article
dc.source.journaltitleNature reviews. Genetics
dc.source.volume11
dc.source.issue8
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/cellbiology_pp/91
dc.identifier.contextkey1421242
html.description.abstract<p>Regulatory machinery is focally organized in the interphase nucleus. The information contained in these focal nuclear microenvironments must be inherited during cell division to sustain physiologically responsive gene expression in progeny cells. Recent results suggest that focal mitotic retention of phenotypic transcription factors at promoters together with histone modifications and DNA methylation--a mechanism collectively known as gene bookmarking--is a novel parameter of inherited epigenetic control that sustains cellular identity after mitosis. The epigenetic signatures imposed by bookmarking poise genes for activation or suppression following mitosis. We discuss the implications of phenotypic transcription factor retention on mitotic chromosomes in biological control and disease.</p>
dc.identifier.submissionpathcellbiology_pp/91
dc.contributor.departmentDepartment of Cell Biology and Cancer Center
dc.source.pages583-9


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