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    Factors correlated with NPPV use in ALS

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    Authors
    Jackson, Carlayne E.
    Lovitt, Steven
    Gowda, Neelam
    Anderson, Frederick A. Jr.
    Miller, Robert G.
    UMass Chan Affiliations
    Center for Outcomes Research
    Document Type
    Journal Article
    Publication Date
    2006-06-07
    Keywords
    Adult
    Amyotrophic Lateral Sclerosis
    Databases, Factual
    Dyspnea
    Female
    Humans
    Income
    Male
    Middle Aged
    Motor Neurons
    Positive-Pressure Respiration
    Sex Factors
    Socioeconomic Factors
    Vital Capacity
    Health Services Research
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    Link to Full Text
    http://dx.doi.org/10.1080/14660820500504587
    Abstract
    In spite of emerging evidence of therapeutic benefit from non-invasive positive pressure ventilation (NPPV), only a minority of ALS patients use this therapy. We examined factors which correlate with use of NPPV in ALS patients. Data were analyzed from the ALS CARE Database on the use of NPPV in patients with FVC less than 50% of predicted and probable or definite ALS based on modified El Escorial criteria. Of the 403 eligible patients, 146 (36%) used NPPV. NPPV compliance was strongly correlated with symptoms of dyspnea and orthopnea as well as with the use of other therapies including PEG tubes, augmentative speech devices, and riluzole. Male gender and household income >$80,000 were also associated with higher NPPV use. There was no correlation between age, race, type of insurance, forced vital capacity, duration of symptoms, ALSFRS-R, caregiver burden or quality of life with the use of NPPV. These data suggest that the factors which are most closely associated with NPPV utilization are symptomatic orthopnea and dyspnea. The findings may be useful in designing prospective studies to examine the factors which might explain the underutilization of NPPV and the optimal use of this treatment.
    Source
    Amyotroph Lateral Scler. 2006 Jun;7(2):80-5. Link to article on publisher's site
    DOI
    10.1080/14660820500504587
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/27097
    PubMed ID
    16753971
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1080/14660820500504587
    Scopus Count
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    ALS C.A.R.E. Publications

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