Use of noninvasive ventilation in patients with amyotrophic lateral sclerosis
Wiener, Charles M.
Davidson, Matthew C.
Anderson, Frederick A. Jr.
Diette, Gregory B.
UMass Chan AffiliationsCenter for Outcomes Research
Document TypeJournal Article
Aged, 80 and over
Amyotrophic Lateral Sclerosis
Intermittent Positive-Pressure Ventilation
Sickness Impact Profile
Health Services Research
MetadataShow full item record
AbstractINTRODUCTION: Noninvasive positive pressure ventilation (NIPPV) is associated with improved survival in amyotrophic lateral sclerosis (ALS) and has been widely recommended. The extent of NIPPV use in ALS patients and the factors associated with its use have not been studied. METHODS: A cross-sectional study using the ALS Patient Care Database. Analyses were performed to assess the association of patient and care characteristics with use of ventilatory support. RESULTS: 1458 patients were studied. 15.6% used NIPPV and 2.1% used invasive mechanical ventilation. Patients who used NIPPV were significantly more likely to be male and have higher income than those who did not. They were also more likely to have a gastrostomy tube, lower vital capacity, more severe disease, bulbar involvement and poorer general health status as measured by the SF-12 and Sickness Impact Profile. Multivariate analysis revealed that lower FVC, higher income and use of gastrostomy tube were independently associated with use of NIPPV. CONCLUSIONS: NIPPV is used more than seven times as frequently as invasive ventilation in ALS patients. Patients who use NIPPV have more severe disease than those who do not use any respiratory intervention. Patients with lower income are less likely to use NIPPV, which raises concerns about disparities in the care of patients with ALS.
SourceAmyotroph Lateral Scler Other Motor Neuron Disord. 2004 Mar;5(1):9-15. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/27100
Related ResourcesLink to Article in PubMed