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    Depression in patients with high-grade glioma: results of the Glioma Outcomes Project

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    Authors
    Litofsky, N. Scott
    Farace, Elana
    Anderson, Frederick A. Jr.
    Meyers, Christina A.
    Huang, Wei
    Laws, Edward R. Jr.
    Glioma Outcomes Investigators
    UMass Chan Affiliations
    Department of Surgery, Division of Neurosurgery
    Center for Outcomes Research
    Document Type
    Journal Article
    Publication Date
    2004-02-01
    Keywords
    Adolescent
    Adult
    Aged
    Aged, 80 and over
    Brain Neoplasms
    Depressive Disorder
    Female
    Glioma
    Humans
    Longitudinal Studies
    Male
    Middle Aged
    Prevalence
    Survival Rate
    Treatment Outcome
    Health Services Research
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    Link to Full Text
    http://dx.doi.org/10.1227/01.NEU.0000103450.94724.A2
    Abstract
    OBJECTIVE: To study the incidence of depression among patients undergoing surgery for high-grade glioma, document factors associated with the presence of depression, and examine the relationship between depression and patient outcome. METHODS: Physician and patient reports of depression were analyzed immediately postoperatively and again 3 and 6 months after surgery for high-grade glioma. Physician-reported depression was defined according to the Diagnostic and Statistical Manual of Mental Disorders, ed 4. Patient self-assessment of depression was based on responses to questions contained in two validated functional status surveys. Concordance of physician- and patient-reported depression was examined, along with the extent of use of pharmacological treatment for depression. Additional outcomes examined included quality of life, survival, patient satisfaction, and posttreatment complications. RESULTS: Data from 598 patients were analyzed. In the early postoperative period, physicians reported depression in 15% of patients, whereas 93% of patients reported symptoms consistent with depression. The incidence of patient self-reported depression remained similar at 3- and 6-month follow-up, whereas physician reported depression increased from 15% in the early postoperative period to 22% at both 3- and 6-month follow-up. Concordance between physician recognition of depression and treatment of depression was low initially (33%) and increased at 3 and 6 months (51 and 60%, respectively). As compared with patients who were not depressed, survival was shorter and complications were more common among depressed patients. CONCLUSION: Symptoms of depression were common immediately after surgery for glioma, and they increased throughout the 6-month period after surgery. These findings support the hypothesis that clinically important depression is a common complication in patients with high-grade glioma. Concordance between physician recognition of depression and self-reports of depression by patients was low. Concordance between physician recognition of depression and initiation of pharmacological antidepressant therapy was fair in the early postoperative period and improved somewhat over the subsequent 6-month period; however, within the 6-month period after surgery for glioma, antidepressant therapy was provided for only 60% of patients in whom the physician recognized depressive symptoms and in only 15% of patients who self-reported symptoms of depression. Findings from this observational study suggest the need for a controlled trial that is designed to test the hypothesis that more attention to the identification of postoperative depression and aggressive treatment of depressive symptoms can improve the quality of life and survival of patients after surgery for high-grade glioma.
    Source
    Neurosurgery. 2004 Feb;54(2):358-66; discussion 366-7.
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/27133
    PubMed ID
    14744282
    Related Resources
    Link to article in PubMed
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    Glioma Outcomes Publications

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