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    Frailty and Fracture, Disability, and Falls: A Multiple Country Study From the Global Longitudinal Study of Osteoporosis in Women

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    Authors
    Tom, Sarah E.
    Adachi, Jonathan D.
    Anderson, Frederick A. Jr.
    Boonen, Steven
    Chapurlat, Roland D.
    Cooper, Cyrus
    Gehlbach, Stephen H.
    Greenspan, Susan L.
    Hooven, Frederick H.
    Nieves, Jeri W.
    Pfeilschifter, Johannes
    Roux, Christian
    Silverman, Stuart
    Wyman, Allison
    LaCroix, Andrea Z.
    GLOW Investigators
    Show allShow less
    UMass Chan Affiliations
    Center for Outcomes Research
    Document Type
    Journal Article
    Publication Date
    2013-01-25
    Keywords
    Osteoporosis
    Frail Elderly
    Accidental Falls
    Fractures, Bone
    Health Services Research
    Musculoskeletal Diseases
    
    Metadata
    Show full item record
    Link to Full Text
    http://dx.doi.org/10.1111/jgs.12146
    Abstract
    Objectives To test whether women aged 55 and older with increasing evidence of a frailty phenotype would have greater risk of fractures, disability, and recurrent falls than women who were not frail, across geographic areas (Australia, Europe, and North America) and age groups. Design Multinational, longitudinal, observational cohort study. Setting Global Longitudinal Study of Osteoporosis in Women (GLOW). Participants Women (N = 48,636) aged 55 and older enrolled at sites in Australia, Europe, and North America. Measurements Components of frailty (slowness and weakness, poor endurance and exhaustion, physical activity, and unintentional weight loss) at baseline and report of fracture, disability, and recurrent falls at 1 year of follow-up were investigated. Women also reported health and demographic characteristics at baseline. Results Women younger than 75 from the United States were more likely to be prefrail and frail than those from Australia, Canada, and Europe. The distribution of frailty was similar according to region for women aged 75 and older. Odds ratios from multivariable models for frailty versus nonfrailty were 1.23 (95% confidence interval (CI) = 1.07–1.42) for fracture, 2.29 (95% CI = 2.09–2.51) for disability, and 1.68 (95% CI = 1.54–1.83) for recurrent falls. The associations for prefrailty versus nonfrailty were weaker but still indicated statistically significantly greater risk of each outcome. Overall, associations between frailty and each outcome were similar across age and geographic region. Conclusion Greater evidence of a frailty phenotype is associated with greater risk of fracture, disability, and falls in women aged 55 and older in 10 countries, with similar patterns across age and geographic region.
    Source
    Tom SE, Adachi JD, Anderson FA, Boonen S, Chapurlat RD, Compston JE, Cooper C, Gehlbach SH, Greenspan SL, Hooven FH, Nieves JW, Pfeilschifter J, Roux C, Silverman S, Wyman A, LaCroix AZ, for the GLOW Investigators. Frailty and Fracture, Disability, and Falls: A Multiple Country Study from the Global Longitudinal Study of Osteoporosis in Women (GLOW). J Am Geriatrics Soc 2012 (in press). DOI: 10.1111/jgs.12146
    DOI
    10.1111/jgs.12146
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/27147
    ae974a485f413a2113503eed53cd6c53
    10.1111/jgs.12146
    Scopus Count
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    GLOW Publications

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