• Login
    View Item 
    •   Home
    • UMass Chan Departments, Programs and Centers
    • Center for Outcomes Research
    • GLOW Publications
    • View Item
    •   Home
    • UMass Chan Departments, Programs and Centers
    • Center for Outcomes Research
    • GLOW Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of eScholarship@UMassChanCommunitiesPublication DateAuthorsUMass Chan AffiliationsTitlesDocument TypesKeywordsThis CollectionPublication DateAuthorsUMass Chan AffiliationsTitlesDocument TypesKeywords

    My Account

    LoginRegister

    Help

    AboutSubmission GuidelinesData Deposit PolicySearchingAccessibilityTerms of UseWebsite Migration FAQ

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Insights from the Global Longitudinal Study of Osteoporosis in Women (GLOW)

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Watts, Nelson B.
    GLOW Investigators
    UMass Chan Affiliations
    Center for Outcomes Research
    Document Type
    Journal Article
    Publication Date
    2014-07-01
    Keywords
    Accidental Falls
    Aged
    Aged, 80 and over
    Comorbidity
    Female
    Hip Fractures
    Hospitalization
    Humans
    Longitudinal Studies
    Middle Aged
    Obesity
    Osteoporosis
    Osteoporosis, Postmenopausal
    Osteoporotic Fractures
    Prevalence
    Quality of Life
    Risk
    Risk Factors
    Spinal Fractures
    Endocrinology, Diabetes, and Metabolism
    Epidemiology
    Health Services Research
    Musculoskeletal Diseases
    Women's Health
    Show allShow less
    
    Metadata
    Show full item record
    Link to Full Text
    http://dx.doi.org/10.1038/nrendo.2014.55
    Abstract
    GLOW is an observational, longitudinal, practice-based cohort study of osteoporosis in 60,393 women aged ≥ 55 years in 10 countries on three continents. In this Review, we present insights from the first 3 years of the study. Despite cost analyses being frequently based on spine and hip fractures, we found that nonvertebral, nonhip fractures were around five times more common and doubled the use of health-care resources compared with hip and spine fractures combined. Fractures not at the four so-called major sites in FRAX(®) (upper arm, forearm, hip and clinical vertebral fractures) account for > 40% of all fractures. The risk of fracture is increased by various comorbidities, such as Parkinson disease, multiple sclerosis and lung and heart disease. Obesity, although thought to be protective against all fractures, substantially increased the risk of fractures in the ankle or lower leg. Simple assessment by age plus fracture history has good predictive value for all fractures, but risk profiles differ for first and subsequent fractures. Fractures diminish quality of life as much or more than diabetes mellitus, arthritis and lung disease, yet women substantially underestimate their own fracture risk. Treatment rates in patients at high risk of fracture are below those recommended but might be too frequent in women at low risk. Comorbidities and the limits of current therapeutic regimens jeopardize the efficacy of drugs; new regimens should be explored for severe cases.
    Source
    Watts NB; GLOW investigators. Insights from the Global Longitudinal Study of Osteoporosis in Women (GLOW). Nat Rev Endocrinol. 2014 Jul;10(7):412-22. doi:10.1038/nrendo.2014.55. Epub 2014 Apr 22. Review. PubMed PMID: 24751880. Link to article on publisher's website
    DOI
    10.1038/nrendo.2014.55
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/27159
    PubMed ID
    24751880
    Related Resources
    Link to article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1038/nrendo.2014.55
    Scopus Count
    Collections
    GLOW Publications

    entitlement

    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Lamar Soutter Library, UMass Chan Medical School | 55 Lake Avenue North | Worcester, MA 01655 USA
    Quick Guide | escholarship@umassmed.edu
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.