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dc.contributor.authorBuysschaert, Ian
dc.contributor.authorCarruthers, Kathryn F.
dc.contributor.authorDunbar, Donald R.
dc.contributor.authorPeuteman, Gilian
dc.contributor.authorRietzschel, Ernst
dc.contributor.authorBelmans, Ann
dc.contributor.authorHedley, Ann
dc.contributor.authorDe Meyer, Tim
dc.contributor.authorBudaj, Andrzej
dc.contributor.authorVan de Werf, Frans
dc.contributor.authorLambrechts, Diether
dc.contributor.authorFox, Keith A. A.
dc.date2022-08-11T08:08:08.000
dc.date.accessioned2022-08-23T15:43:46Z
dc.date.available2022-08-23T15:43:46Z
dc.date.issued2010-05-17
dc.date.submitted2011-09-23
dc.identifier.citation<p>Eur Heart J. 2010 May;31(9):1132-41. Epub 2010 Mar 15. <a href="http://dx.doi.org/10.1093/eurheartj/ehq053">Link to article on publisher's site</a></p>
dc.identifier.issn0195-668X (Linking)
dc.identifier.doi10.1093/eurheartj/ehq053
dc.identifier.pmid20231156
dc.identifier.urihttp://hdl.handle.net/20.500.14038/27169
dc.description.abstractAIMS: Recent genetic studies identified the rs1333049 variant on chromosome 9p21 as a major susceptibility locus for coronary artery disease and myocardial infarction (MI). Here, we evaluated whether this variant also contributes to recurrent MI or cardiac death following an acute coronary syndrome (ACS). METHODS AND RESULTS: A total of 3247 patients with ACS enrolled in the Global Registry of Acute Coronary Events (GRACE) in three distinct populations (UK, Belgium and Poland) were prospectively followed for 6 months and genotyped for rs1333049, in addition to 3004 and 2467 healthy controls from the UK and Belgium. After having confirmed that the at-risk C allele of rs1333049 was associated with index ACS in the UK and Belgian populations, we found that the rs1333049 at-risk C allele was significantly and independently associated with recurrent MI [age- and gender-adjusted hazard ratio (HR) 1.48, CI = 1.00-2.19, P = 0.048; and multivariable-adjusted HR 1.47, CI = 0.99-2.18; P = 0.053] and with recurrent MI or cardiac death (age- and gender-adjusted HR 1.58, CI = 1.00-2.48; P = 0.045; and multivariable adjusted HR 1.49, CI = 1.03-1.98; P = 0.028) within 6 months after an index ACS. Inclusion of rs1333049 into the GRACE risk score significantly improved classification for recurrent MI or cardiac death (P = 0.040), as calculated by the integrated discrimination improvement method. CONCLUSION: In this large observational study, the 9p21 variant was independently associated with adverse cardiac outcome after ACS.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=20231156&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862180
dc.subjectAcute Coronary Syndrome
dc.subjectAged
dc.subjectChromosomes, Human, Pair 9
dc.subjectDeath, Sudden, Cardiac
dc.subjectFemale
dc.subject*Genes, p16
dc.subjectGenetic Predisposition to Disease
dc.subjectGenetic Testing
dc.subjectGenotype
dc.subjectHospitalization
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMyocardial Infarction
dc.subjectPolymorphism, Single Nucleotide
dc.subjectProspective Studies
dc.subjectRecurrence
dc.subjectRegistries
dc.subjectRisk Factors
dc.subjectChromosome 9p21
dc.subjectRs1333049
dc.subjectGenetics
dc.subjectAcute coronary syndrome
dc.subjectMyocardial infarction
dc.subjectPlaque rupture
dc.subjectCardiovascular System
dc.subjectCells
dc.subjectGenetic Phenomena
dc.subjectGenetics
dc.subjectHealth Services Research
dc.subjectInvestigative Techniques
dc.subjectPathological Conditions, Signs and Symptoms
dc.titleA variant at chromosome 9p21 is associated with recurrent myocardial infarction and cardiac death after acute coronary syndrome: the GRACE Genetics Study
dc.typeJournal Article
dc.source.journaltitleEuropean heart journal
dc.source.volume31
dc.source.issue9
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/cor_grace/1
dc.identifier.contextkey2254919
html.description.abstract<p>AIMS: Recent genetic studies identified the rs1333049 variant on chromosome 9p21 as a major susceptibility locus for coronary artery disease and myocardial infarction (MI). Here, we evaluated whether this variant also contributes to recurrent MI or cardiac death following an acute coronary syndrome (ACS).</p> <p>METHODS AND RESULTS: A total of 3247 patients with ACS enrolled in the Global Registry of Acute Coronary Events (GRACE) in three distinct populations (UK, Belgium and Poland) were prospectively followed for 6 months and genotyped for rs1333049, in addition to 3004 and 2467 healthy controls from the UK and Belgium. After having confirmed that the at-risk C allele of rs1333049 was associated with index ACS in the UK and Belgian populations, we found that the rs1333049 at-risk C allele was significantly and independently associated with recurrent MI [age- and gender-adjusted hazard ratio (HR) 1.48, CI = 1.00-2.19, P = 0.048; and multivariable-adjusted HR 1.47, CI = 0.99-2.18; P = 0.053] and with recurrent MI or cardiac death (age- and gender-adjusted HR 1.58, CI = 1.00-2.48; P = 0.045; and multivariable adjusted HR 1.49, CI = 1.03-1.98; P = 0.028) within 6 months after an index ACS. Inclusion of rs1333049 into the GRACE risk score significantly improved classification for recurrent MI or cardiac death (P = 0.040), as calculated by the integrated discrimination improvement method.</p> <p>CONCLUSION: In this large observational study, the 9p21 variant was independently associated with adverse cardiac outcome after ACS.</p>
dc.identifier.submissionpathcor_grace/1
dc.contributor.departmentCenter for Outcomes Research
dc.source.pages1132-41


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