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dc.contributor.authorMcManus, David D.
dc.contributor.authorHuang, Wei
dc.contributor.authorDomakonda, Kunal V.
dc.contributor.authorWard, Jeanine
dc.contributor.authorSaczynski, Jane S.
dc.contributor.authorGore, Joel M.
dc.contributor.authorGoldberg, Robert J.
dc.date2022-08-11T08:08:08.000
dc.date.accessioned2022-08-23T15:43:48Z
dc.date.available2022-08-23T15:43:48Z
dc.date.issued2012-11-01
dc.date.submitted2012-11-09
dc.identifier.citation<p>McManus DD, Huang W, Domakonda KV, Ward J, Saczysnki JS, Gore JM, Goldberg RJ. Trends in atrial fibrillation in patients hospitalized with an acute coronary syndrome. Am J Med. 2012 Nov;125(11):1076-84. doi: 10.1016/j.amjmed.2012.05.024.</p>
dc.identifier.issn1555-7162
dc.identifier.doi10.1016/j.amjmed.2012.05.024
dc.identifier.pmid23098864
dc.identifier.urihttp://hdl.handle.net/20.500.14038/27175
dc.description.abstractBACKGROUND: Atrial fibrillation is common among patients with cardiovascular disease and is a frequent complication of the acute coronary syndrome. Data are needed on recent trends in the magnitude, clinical features, treatment, and prognostic impact of preexisting and new-onset atrial fibrillation in patients hospitalized with an acute coronary syndrome. METHODS: The study population consisted of 59,032 patients hospitalized with an acute coronary syndrome at 113 sites in the Global Registry of Acute Coronary Events Study between 2000 and 2007. RESULTS: A total of 4494 participants (7.6%) with acute coronary syndrome reported a history of atrial fibrillation and 3112 participants (5.3%) developed new-onset atrial fibrillation during their hospitalization. Rates of new-onset atrial fibrillation (5.5%-4.5%) and preexisting atrial fibrillation (7.4%-6.7%) declined during the study. Preexisting atrial fibrillation was associated with older age and greater cardiovascular disease burden, whereas new-onset atrial fibrillation was closely related to the severity of the index acute coronary syndrome. Patients with atrial fibrillation were less likely than patients without atrial fibrillation to receive evidence-based therapies and more likely to develop in-hospital complications, including heart failure. Overall hospital death rates in patients with new-onset and preexisting atrial fibrillation were 14.5% and 8.9%, respectively, compared with 1.2% in those without atrial fibrillation. Short-term death rates in patients with atrial fibrillation declined over the study period. CONCLUSIONS: Despite a reduction in the rates of, and mortality from, atrial fibrillation, this arrhythmia exerts a significant adverse effect on survival among patients hospitalized with an acute coronary syndrome. Opportunities exist to improve the identification and treatment of patients with acute coronary syndrome with, or at risk for, atrial fibrillation to reduce the incidence and resultant complications of this dysrhythmia.
dc.language.isoen_US
dc.publisherExcerpta Medica
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23098864&dopt=Abstract">Link to article in PubMed</a></p>
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524515/
dc.subjectAtrial Fibrillation
dc.subjectAcute Coronary Syndrome
dc.subjectHospitalization
dc.subjectOutcome Assessment (Health Care)
dc.subjectUMCCTS funding
dc.subjectCardiovascular Diseases
dc.subjectHealth Services Research
dc.titleTrends in atrial fibrillation in patients hospitalized with an acute coronary syndrome
dc.typeJournal Article
dc.source.journaltitleThe American journal of medicine
dc.source.volume125
dc.source.issue11
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/cor_grace/104
dc.identifier.contextkey3457870
html.description.abstract<p>BACKGROUND: Atrial fibrillation is common among patients with cardiovascular disease and is a frequent complication of the acute coronary syndrome. Data are needed on recent trends in the magnitude, clinical features, treatment, and prognostic impact of preexisting and new-onset atrial fibrillation in patients hospitalized with an acute coronary syndrome.</p> <p>METHODS: The study population consisted of 59,032 patients hospitalized with an acute coronary syndrome at 113 sites in the Global Registry of Acute Coronary Events Study between 2000 and 2007.</p> <p>RESULTS: A total of 4494 participants (7.6%) with acute coronary syndrome reported a history of atrial fibrillation and 3112 participants (5.3%) developed new-onset atrial fibrillation during their hospitalization. Rates of new-onset atrial fibrillation (5.5%-4.5%) and preexisting atrial fibrillation (7.4%-6.7%) declined during the study. Preexisting atrial fibrillation was associated with older age and greater cardiovascular disease burden, whereas new-onset atrial fibrillation was closely related to the severity of the index acute coronary syndrome. Patients with atrial fibrillation were less likely than patients without atrial fibrillation to receive evidence-based therapies and more likely to develop in-hospital complications, including heart failure. Overall hospital death rates in patients with new-onset and preexisting atrial fibrillation were 14.5% and 8.9%, respectively, compared with 1.2% in those without atrial fibrillation. Short-term death rates in patients with atrial fibrillation declined over the study period.</p> <p>CONCLUSIONS: Despite a reduction in the rates of, and mortality from, atrial fibrillation, this arrhythmia exerts a significant adverse effect on survival among patients hospitalized with an acute coronary syndrome. Opportunities exist to improve the identification and treatment of patients with acute coronary syndrome with, or at risk for, atrial fibrillation to reduce the incidence and resultant complications of this dysrhythmia.</p>
dc.identifier.submissionpathcor_grace/104
dc.contributor.departmentMeyers Primary Care Institute
dc.contributor.departmentDepartment of Emergency Medicine
dc.contributor.departmentCenter for Outcomes Research
dc.contributor.departmentDepartment of Quantitative Health Sciences
dc.contributor.departmentDepartment of Medicine, Division of Cardiovascular Medicine
dc.source.pages1076-84


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