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dc.contributor.authorFox, Keith A. A.
dc.contributor.authorSteg, Phillippe Gabriel
dc.contributor.authorEagle, Kim A.
dc.contributor.authorGoodman, Shaun G.
dc.contributor.authorAnderson, Frederick A. Jr.
dc.contributor.authorGranger, Christopher B.
dc.contributor.authorFlather, Marcus D.
dc.contributor.authorBudaj, Andrzej
dc.contributor.authorQuill, Ann L.
dc.contributor.authorGore, Joel M.
dc.date2022-08-11T08:08:08.000
dc.date.accessioned2022-08-23T15:44:01Z
dc.date.available2022-08-23T15:44:01Z
dc.date.issued2007-05-03
dc.date.submitted2011-09-23
dc.identifier.citationJAMA. 2007 May 2;297(17):1892-900. <a href="http://dx.doi.org/10.1001/jama.297.17.1892">Link to article on publisher's site</a>
dc.identifier.issn0098-7484 (Linking)
dc.identifier.doi10.1001/jama.297.17.1892
dc.identifier.pmid17473299
dc.identifier.urihttp://hdl.handle.net/20.500.14038/27224
dc.description.abstractCONTEXT: Randomized trials provide robust evidence for the impact of pharmacological and interventional treatments in patients with ST-segment elevation and non-ST-segment elevation acute coronary syndromes (NSTE ACS), but whether this translates to changes in clinical practice is unknown. OBJECTIVE: To determine whether changes in hospital management of patients with ST-segment elevation myocardial infarction (STEMI) and NSTE ACS are associated with improvements in clinical outcome. DESIGN, SETTING AND PATIENTS: In the Global Registry of Acute Coronary Events (GRACE), a multinational cohort study, 44 372 patients with an ACS were enrolled and followed up in 113 hospitals in 14 countries between July 1, 1999, and December 31, 2006. MAIN OUTCOME MEASURES: Temporal trends in the use of evidence-based pharmacological and interventional therapies; patient outcomes (death, congestive heart failure, pulmonary edema, cardiogenic shock, stroke, myocardial infarction). RESULTS: Use of pharmacological medications increased over the study period (beta-blockers, statins, angiotensin-converting enzyme inhibitors, thienopyridines with or without percutaneous coronary intervention [PCI], glycoprotein IIb/IIIa inhibitors, low-molecular-weight heparin; all P<.001). Pharmacological reperfusion declined in patients with STEMI by -22 percentage points (95% confidence interval [CI], -27 to -17), whereas primary PCI increased by 37 percentage points (95% CI, 33-41). In patients with non-STEMI, rates of PCI increased markedly by 18 percentage points (95% CI, 15-20). Rates of congestive heart failure and pulmonary edema declined in both populations: STEMI, -9 percentage points (95% CI, -12 to -6) and NSTE ACS, -6.9 percentage points (95% CI, -8.4 to -4.7). In patients with STEMI, hospital deaths decreased by 18 percentage points (95% CI, -5.3 to -1.9) and cardiogenic shock by -24 percentage points (95% CI, -4.3 to -0.5). Risk-adjusted hospital deaths declined -0.7 percentage points (95% CI, -1.7 to 0.3) in NSTE ACS patients. Six-month follow-up rates declined among STEMI patients: stroke by -0.8 percentage points (95% CI, -1.7 to 0.1) and myocardial infarction by -2.8 percentage points (95% CI, -6.4 to 0.9). In NSTE ACS, 6-month death declined -1.6 percentage points (95% CI, -3.0 to -0.1) and stroke by 0.7 percentage points (95% CI, -1.4 to 0.1). CONCLUSIONS: In this multinational observational study, improvements in the management of patients with ACS were associated with significant reductions in the rates of new heart failure and mortality and in rates of stroke and mycoardial infarction at 6 months.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=17473299&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1001/jama.297.17.1892
dc.subjectAged
dc.subjectAngina, Unstable
dc.subjectCardiology
dc.subjectFemale
dc.subjectHospitalization
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMyocardial Infarction
dc.subjectRegistries
dc.subjectTreatment Outcome
dc.subjectHealth Services Research
dc.titleDecline in rates of death and heart failure in acute coronary syndromes, 1999-2006
dc.typeJournal Article
dc.source.journaltitleJAMA : the journal of the American Medical Association
dc.source.volume297
dc.source.issue17
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/cor_grace/42
dc.identifier.contextkey2254961
html.description.abstract<p>CONTEXT: Randomized trials provide robust evidence for the impact of pharmacological and interventional treatments in patients with ST-segment elevation and non-ST-segment elevation acute coronary syndromes (NSTE ACS), but whether this translates to changes in clinical practice is unknown.</p> <p>OBJECTIVE: To determine whether changes in hospital management of patients with ST-segment elevation myocardial infarction (STEMI) and NSTE ACS are associated with improvements in clinical outcome.</p> <p>DESIGN, SETTING AND PATIENTS: In the Global Registry of Acute Coronary Events (GRACE), a multinational cohort study, 44 372 patients with an ACS were enrolled and followed up in 113 hospitals in 14 countries between July 1, 1999, and December 31, 2006.</p> <p>MAIN OUTCOME MEASURES: Temporal trends in the use of evidence-based pharmacological and interventional therapies; patient outcomes (death, congestive heart failure, pulmonary edema, cardiogenic shock, stroke, myocardial infarction).</p> <p>RESULTS: Use of pharmacological medications increased over the study period (beta-blockers, statins, angiotensin-converting enzyme inhibitors, thienopyridines with or without percutaneous coronary intervention [PCI], glycoprotein IIb/IIIa inhibitors, low-molecular-weight heparin; all P<.001). Pharmacological reperfusion declined in patients with STEMI by -22 percentage points (95% confidence interval [CI], -27 to -17), whereas primary PCI increased by 37 percentage points (95% CI, 33-41). In patients with non-STEMI, rates of PCI increased markedly by 18 percentage points (95% CI, 15-20). Rates of congestive heart failure and pulmonary edema declined in both populations: STEMI, -9 percentage points (95% CI, -12 to -6) and NSTE ACS, -6.9 percentage points (95% CI, -8.4 to -4.7). In patients with STEMI, hospital deaths decreased by 18 percentage points (95% CI, -5.3 to -1.9) and cardiogenic shock by -24 percentage points (95% CI, -4.3 to -0.5). Risk-adjusted hospital deaths declined -0.7 percentage points (95% CI, -1.7 to 0.3) in NSTE ACS patients. Six-month follow-up rates declined among STEMI patients: stroke by -0.8 percentage points (95% CI, -1.7 to 0.1) and myocardial infarction by -2.8 percentage points (95% CI, -6.4 to 0.9). In NSTE ACS, 6-month death declined -1.6 percentage points (95% CI, -3.0 to -0.1) and stroke by 0.7 percentage points (95% CI, -1.4 to 0.1).</p> <p>CONCLUSIONS: In this multinational observational study, improvements in the management of patients with ACS were associated with significant reductions in the rates of new heart failure and mortality and in rates of stroke and mycoardial infarction at 6 months.</p>
dc.identifier.submissionpathcor_grace/42
dc.contributor.departmentDepartment of Medicine, Division of Cardiovascular Medicine
dc.contributor.departmentDepartment of Surgery
dc.contributor.departmentCenter for Outcomes Research
dc.source.pages1892-900


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