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dc.contributor.authorYan, Raymond T.
dc.contributor.authorYan, Andrew T.
dc.contributor.authorAllegrone, Jeanna
dc.contributor.authorLopez-Sendon, Jose
dc.contributor.authorGranger, Christopher B.
dc.contributor.authorGore, Joel M.
dc.contributor.authorBudaj, Andrzej
dc.contributor.authorGeorgescue, Alina A.
dc.contributor.authorHassan, Quamrul
dc.contributor.authorLuchansky, Janna
dc.contributor.authorVan de Werf, Frans
dc.contributor.authorGoodman, Shaun G.
dc.date2022-08-11T08:08:08.000
dc.date.accessioned2022-08-23T15:44:04Z
dc.date.available2022-08-23T15:44:04Z
dc.date.issued2007-07-17
dc.date.submitted2011-09-23
dc.identifier.citationAm J Cardiol. 2007 Jul 15;100(2):169-74. Epub 2007 Jun 4. <a href="http://dx.doi.org/10.1016/j.amjcard.2007.02.074">Link to article on publisher's site</a>
dc.identifier.issn0002-9149 (Linking)
dc.identifier.doi10.1016/j.amjcard.2007.02.074
dc.identifier.pmid17631063
dc.identifier.urihttp://hdl.handle.net/20.500.14038/27234
dc.description.abstractIn the prospective, multinational Global Registry of Acute Coronary Events (GRACE), patients diagnosed with non-ST-elevation acute coronary syndromes had their admission electrocardiogram independently evaluated by a central core laboratory, and its interpretation by the core laboratory and enrolling site were compared. One in 6 of these patients had clinically important features of left-bundle branch block or ST-segment deviation diagnosed by the core laboratory that were apparently not recognized at the local sites; this subgroup of patients was less likely to undergo risk stratification and revascularization. Importantly, failure to recognize these features as confirmed by the core laboratory in routine clinical practice was independently associated with higher mortality and recurrent myocardial infarction at 6 months (adjusted odds ratio 1.41, 95% confidence interval 1.01 to 1.96, p = 0.043). In conclusion, these findings underscore an urgent need to promote more accurate interpretation of electrocardiograms in contemporary clinical practice to bridge treatment gaps and improve patient outcome.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=17631063&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1016/j.amjcard.2007.02.074
dc.subjectAged
dc.subjectCoronary Disease
dc.subjectDiagnostic Tests, Routine
dc.subjectElectrocardiography
dc.subjectFemale
dc.subjectHumans
dc.subjectLaboratories
dc.subjectMale
dc.subjectMyocardial Infarction
dc.subjectProspective Studies
dc.subjectHealth Services Research
dc.titleDifferences between local hospital and core laboratory interpretation of the admission electrocardiogram in patients with acute coronary syndromes and their relation to outcome
dc.typeArticle
dc.source.journaltitleThe American journal of cardiology
dc.source.volume100
dc.source.issue2
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/cor_grace/54
dc.identifier.contextkey2254974
html.description.abstract<p>In the prospective, multinational Global Registry of Acute Coronary Events (GRACE), patients diagnosed with non-ST-elevation acute coronary syndromes had their admission electrocardiogram independently evaluated by a central core laboratory, and its interpretation by the core laboratory and enrolling site were compared. One in 6 of these patients had clinically important features of left-bundle branch block or ST-segment deviation diagnosed by the core laboratory that were apparently not recognized at the local sites; this subgroup of patients was less likely to undergo risk stratification and revascularization. Importantly, failure to recognize these features as confirmed by the core laboratory in routine clinical practice was independently associated with higher mortality and recurrent myocardial infarction at 6 months (adjusted odds ratio 1.41, 95% confidence interval 1.01 to 1.96, p = 0.043). In conclusion, these findings underscore an urgent need to promote more accurate interpretation of electrocardiograms in contemporary clinical practice to bridge treatment gaps and improve patient outcome.</p>
dc.identifier.submissionpathcor_grace/54
dc.contributor.departmentDepartment of Medicine, Division of Cardiovascular Medicine
dc.contributor.departmentCenter for Outcomes Research
dc.source.pages169-74


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