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    Circulating secretory phospholipase A2 activity predicts recurrent events in patients with severe acute coronary syndromes

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    Authors
    Mallat, Ziad
    Steg, Phillippe Gabriel
    Benessiano, Joelle
    Tanguy, Marie-Laure
    Fox, Keith A. A.
    Collet, Jean-Philippe
    Dabbous, Omar H.
    Henry, Patrick
    Carruthers, Kathryn F.
    Dauphin, Anne
    Arguelles, Carla Sibella
    Masliah, Joelle
    Hugel, Benedicte
    Montalescot, Gilles
    Freyssinet, Jean-Marie
    Asselain, Bernard
    Tedgui, Alain
    Show allShow less
    UMass Chan Affiliations
    Center for Outcomes Research
    Document Type
    Journal Article
    Publication Date
    2005-10-04
    Keywords
    Acute Disease
    Angina, Unstable
    C-Reactive Protein
    Female
    Humans
    Interleukin-18
    Male
    Middle Aged
    Myocardial Infarction
    Phospholipases A
    Phospholipases A2
    Prognosis
    Recurrence
    Severity of Illness Index
    Health Services Research
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    Link to Full Text
    http://dx.doi.org/10.1016/j.jacc.2005.06.056
    Abstract
    OBJECTIVES: The purpose of this study was to determine the prognostic value of circulating secretory phospholipase A2 (sPLA2) activity in patients with acute coronary syndromes (ACS). BACKGROUND: The plasma level of type IIA sPLA2 is a risk factor for coronary artery disease (CAD) and is associated with adverse outcomes in patients with stable CAD. The prognostic impact of sPLA2 in patients with ACS is unknown. METHODS: Secretory phospholipase A2 antigen levels and activity were measured in plasma samples of 446 patients with ACS, obtained at the time of enrollment. RESULTS: Baseline sPLA2 activity was associated with the risk of death and myocardial infarction (MI). The unadjusted rate of death and MI increased in a stepwise fashion with increasing tertiles of sPLA2 activity (p < 0.0001). The association remained significant in the subgroup of patients who had MI with ST-segment elevation (p = 0.014) and the subgroup of patients who had unstable angina or non-ST-segment elevation MI (p < 0.002). After adjustment for clinical and biological variables, the hazard ratios for the combined end point of death or MI in the third tertile of sPLA2 compared with the first and second tertiles was 3.08 (95% confidence interval, 1.37 to 6.91, p = 0.006). CONCLUSIONS: A single measurement of plasma sPLA2 activity at the time of enrollment provides strong independent information to predict recurrent events in patients with ACS.
    Source
    J Am Coll Cardiol. 2005 Oct 4;46(7):1249-57. Link to article on publisher's site
    DOI
    10.1016/j.jacc.2005.06.056
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/27252
    PubMed ID
    16198839
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.jacc.2005.06.056
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