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dc.contributor.authorSaheera, Sherin
dc.contributor.authorPotnuri, Ajay Godwin
dc.contributor.authorKrishnamurthy, Prasanna
dc.date2022-08-11T08:08:09.000
dc.date.accessioned2022-08-23T15:44:28Z
dc.date.available2022-08-23T15:44:28Z
dc.date.issued2020-08-26
dc.date.submitted2020-09-07
dc.identifier.citation<p>Saheera S, Potnuri AG, Krishnamurthy P. Nano-Vesicle (Mis)Communication in Senescence-Related Pathologies. Cells. 2020 Aug 26;9(9):E1974. doi: 10.3390/cells9091974. PMID: 32859053. <a href="https://doi.org/10.3390/cells9091974" target="_blank" title="View article on publisher's website">View article on publisher's website</a></p>
dc.identifier.issn2073-4409
dc.identifier.doi10.3390/cells9091974
dc.identifier.pmid32859053
dc.identifier.urihttp://hdl.handle.net/20.500.14038/27322
dc.description.abstractExtracellular vesicles are a heterogeneous group of cell-derived membranous structures comprising of exosomes, apoptotic bodies, and microvesicles. Of the extracellular vesicles, exosomes are the most widely sorted and extensively explored for their contents and function. The size of the nanovesicular structures (exosomes) range from 30 to 140 nm and are present in various biological fluids such as saliva, plasma, urine etc. These cargo-laden extracellular vesicles arise from endosome-derived multivesicular bodies and are known to carry proteins and nucleic acids. Exosomes are involved in multiple physiological and pathological processes, including cellular senescence. Exosomes mediate signaling crosstalk and play a critical role in cell-cell communications. Exosomes have evolved as potential biomarkers for aging-related diseases. Aging, a physiological process, involves a progressive decline of function of organs with a loss of homeostasis and increasing probability of illness and death. The review focuses on the classic view of exosome biogenesis, biology, and age-associated changes. Owing to their ability to transport biological information among cells, the review also discusses the interplay of senescent cell-derived exosomes with the aging process, including the susceptibility of the aging population to COVID-19 infections.
dc.language.isoen_US
dc.relation<p><a href="https://pubmed.ncbi.nlm.nih.gov/32859053/" target="_blank" title="View article in PubMed">View article in PubMed</a></p>
dc.rights© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCOVID-19
dc.subjectaging
dc.subjectexosomes
dc.subjectextracellular vesicles
dc.subjectmiRNA
dc.subjectAmino Acids, Peptides, and Proteins
dc.subjectCell Biology
dc.subjectCells
dc.subjectCellular and Molecular Physiology
dc.subjectImmunology and Infectious Disease
dc.subjectInfectious Disease
dc.subjectNucleic Acids, Nucleotides, and Nucleosides
dc.subjectPhysiological Processes
dc.subjectVirus Diseases
dc.titleNano-Vesicle (Mis)Communication in Senescence-Related Pathologies
dc.typeJournal Article
dc.source.journaltitleCells
dc.source.volume9
dc.source.issue9
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1107&amp;context=covid19&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/covid19/108
dc.identifier.contextkey19287749
refterms.dateFOA2022-08-23T15:44:29Z
html.description.abstract<p>Extracellular vesicles are a heterogeneous group of cell-derived membranous structures comprising of exosomes, apoptotic bodies, and microvesicles. Of the extracellular vesicles, exosomes are the most widely sorted and extensively explored for their contents and function. The size of the nanovesicular structures (exosomes) range from 30 to 140 nm and are present in various biological fluids such as saliva, plasma, urine etc. These cargo-laden extracellular vesicles arise from endosome-derived multivesicular bodies and are known to carry proteins and nucleic acids. Exosomes are involved in multiple physiological and pathological processes, including cellular senescence. Exosomes mediate signaling crosstalk and play a critical role in cell-cell communications. Exosomes have evolved as potential biomarkers for aging-related diseases. Aging, a physiological process, involves a progressive decline of function of organs with a loss of homeostasis and increasing probability of illness and death. The review focuses on the classic view of exosome biogenesis, biology, and age-associated changes. Owing to their ability to transport biological information among cells, the review also discusses the interplay of senescent cell-derived exosomes with the aging process, including the susceptibility of the aging population to COVID-19 infections.</p>
dc.identifier.submissionpathcovid19/108
dc.contributor.departmentDepartment of Medicine, Division of Cardiovascular Medicine
dc.source.pages1974


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© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Except where otherwise noted, this item's license is described as © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).