ACEing COVID-19: A Role For Angiotensin Axis Inhibition in SARS-CoV-2 infection
UMass Chan AffiliationsDepartment of Medicine, Division of Cardiovascular Medicine
Immunology and Infectious Disease
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AbstractCardiometabolic disease, especially hypertension, is a common risk factor for mortality among individuals with SARS-CoV-2 disease (COVID-19). The role of hypertension and vascular disease in COVID-19 has raised considerable debate around how to best manage anti-hypertensive therapy to alter disease trajectory. Given the role of the ACE2 receptor in SARS-CoV-2 viral entry6, angiotensin system modulation by ACE inhibitors (ACE-I) or angiotensin-II receptor blockers (ARBs) in clinical management have taken center stage in this controversy.
Murthy VL, Koupenova M, Shah RV. ACEing COVID-19: A Role for Angiotensin Axis Inhibition in SARS-CoV-2 Infection? Circ Res. 2020 Jun 5;126(12):1682-1684. doi: 10.1161/CIRCRESAHA.120.317174. Epub 2020 Apr 17. PMID: 32302248; PMCID: PMC7274880. Link to article on publisher's site