Coagulopathy, endothelial dysfunction, thrombotic microangiopathy and complement activation: potential role of complement system inhibition in COVID-19
UMass Chan AffiliationsDepartment of Medicine, Hematology and Oncology
Document TypeJournal Article
Fluids and Secretions
Hemic and Immune Systems
Hemic and Lymphatic Diseases
Respiratory Tract Diseases
MetadataShow full item record
AbstractCoronavirus disease-2019 (COVID-19) is a rapidly evolving health crisis caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is a novel disease entity and we are in a learning phase with regards to the pathogenesis, disease manifestations, and therapeutics. In addition to the primary lung injury, many patients especially the ones with moderate to severe COVID-19 display evidence of endothelial damage, complement activation, which leads to a pro-coagulable state. While there are still missing links in our understanding, the interplay of endothelium, complement system activation, and immune response to the SARS-CoV-2 virus is a surprisingly major factor in COVID-19 pathogenesis. One could envision COVID-19 becoming a novel hematological syndrome. This review is to discuss the available literature with regards to the involvement of the complement system, and coagulation cascade and their interaction with endothelium.
Wang X, Sahu KK, Cerny J. Coagulopathy, endothelial dysfunction, thrombotic microangiopathy and complement activation: potential role of complement system inhibition in COVID-19. J Thromb Thrombolysis. 2020 Oct 15:1–6. doi: 10.1007/s11239-020-02297-z. Epub ahead of print. PMID: 33063256; PMCID: PMC7561230. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/27349
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