Coagulopathy, endothelial dysfunction, thrombotic microangiopathy and complement activation: potential role of complement system inhibition in COVID-19
| dc.contributor.author | Wang, Xin | |
| dc.contributor.author | Sahu, Kamal Kant | |
| dc.contributor.author | Cerny, Jan | |
| dc.date | 2022-08-11T08:08:09.000 | |
| dc.date.accessioned | 2022-08-23T15:44:36Z | |
| dc.date.available | 2022-08-23T15:44:36Z | |
| dc.date.issued | 2020-10-15 | |
| dc.date.submitted | 2020-10-26 | |
| dc.identifier.citation | <p>Wang X, Sahu KK, Cerny J. Coagulopathy, endothelial dysfunction, thrombotic microangiopathy and complement activation: potential role of complement system inhibition in COVID-19. J Thromb Thrombolysis. 2020 Oct 15:1–6. doi: 10.1007/s11239-020-02297-z. Epub ahead of print. PMID: 33063256; PMCID: PMC7561230. <a href="https://doi.org/10.1007/s11239-020-02297-z">Link to article on publisher's site</a></p> | |
| dc.identifier.issn | 0929-5305 (Linking) | |
| dc.identifier.doi | 10.1007/s11239-020-02297-z | |
| dc.identifier.pmid | 33063256 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14038/27349 | |
| dc.description.abstract | Coronavirus disease-2019 (COVID-19) is a rapidly evolving health crisis caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is a novel disease entity and we are in a learning phase with regards to the pathogenesis, disease manifestations, and therapeutics. In addition to the primary lung injury, many patients especially the ones with moderate to severe COVID-19 display evidence of endothelial damage, complement activation, which leads to a pro-coagulable state. While there are still missing links in our understanding, the interplay of endothelium, complement system activation, and immune response to the SARS-CoV-2 virus is a surprisingly major factor in COVID-19 pathogenesis. One could envision COVID-19 becoming a novel hematological syndrome. This review is to discuss the available literature with regards to the involvement of the complement system, and coagulation cascade and their interaction with endothelium. | |
| dc.language.iso | en_US | |
| dc.relation | <p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=33063256&dopt=Abstract">Link to Article in PubMed</a></p> | |
| dc.relation.url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7561230/ | |
| dc.subject | COVID-19 | |
| dc.subject | Coronavirus | |
| dc.subject | Immunity | |
| dc.subject | Pandemic | |
| dc.subject | Cardiovascular Diseases | |
| dc.subject | Fluids and Secretions | |
| dc.subject | Hematology | |
| dc.subject | Hemic and Immune Systems | |
| dc.subject | Hemic and Lymphatic Diseases | |
| dc.subject | Immunity | |
| dc.subject | Infectious Disease | |
| dc.subject | Respiratory Tract Diseases | |
| dc.subject | Virus Diseases | |
| dc.title | Coagulopathy, endothelial dysfunction, thrombotic microangiopathy and complement activation: potential role of complement system inhibition in COVID-19 | |
| dc.type | Journal Article | |
| dc.source.journaltitle | Journal of thrombosis and thrombolysis | |
| dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/covid19/140 | |
| dc.identifier.contextkey | 19982556 | |
| html.description.abstract | <p>Coronavirus disease-2019 (COVID-19) is a rapidly evolving health crisis caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is a novel disease entity and we are in a learning phase with regards to the pathogenesis, disease manifestations, and therapeutics. In addition to the primary lung injury, many patients especially the ones with moderate to severe COVID-19 display evidence of endothelial damage, complement activation, which leads to a pro-coagulable state. While there are still missing links in our understanding, the interplay of endothelium, complement system activation, and immune response to the SARS-CoV-2 virus is a surprisingly major factor in COVID-19 pathogenesis. One could envision COVID-19 becoming a novel hematological syndrome. This review is to discuss the available literature with regards to the involvement of the complement system, and coagulation cascade and their interaction with endothelium.</p> | |
| dc.identifier.submissionpath | covid19/140 | |
| dc.contributor.department | Department of Medicine, Hematology and Oncology |
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