SARS-CoV-2 Vaccination and Solid Organ Transplant Patients: Data Needed to Inform Safety and Efficacy
AuthorsIson, Michael G.
Theodoropoulos, Nicole M.
Wolfe, Cameron R.
UMass Chan AffiliationsDepartment of Medicine, Division of Infectious Diseases and Immunology
Document TypeJournal Article
Immunology and Infectious Disease
Surgical Procedures, Operative
MetadataShow full item record
AbstractSolid organ transplant (SOT) recipients appear to have higher rates of mortality from COVID-19 when compared to other populations, attributed to underlying immunosuppression and concomitant co-morbidities.1 Such findings are consistent with other respiratory viral infections that are associated with an increased risk of morbidity and mortality in immunocompromised hosts.2 Further, these patients experience prolonged SARS-CoV-2 shedding which has been linked to emergence of viral mutants. Prolonged shedding also poses a risk of transmission and requires prolonged isolation, potentially leading to delays in medical care.
Ison MG, Avery R, Blumberg E, Chin-Hong P, Halasa N, Kaul D, Pergam S, Theodoropoulos NM, Wolfe CR. SARS-CoV-2 Vaccination and Solid Organ Transplant Patients: Data Needed to Inform Safety and Efficacy. Transplantation. 2021 Mar 10. doi: 10.1097/TP.0000000000003747. Epub ahead of print. PMID: 33724250. Link to article on publisher's site