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    Antibodies, boosters and optimizing SARS-CoV-2 vaccine for transplantation: A call for more research

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    Authors
    Ison, Michael G.
    Blumberg, Emily
    Halasa, Natasha
    Kaul, Dan
    Theodoropoulos, Nicole M.
    Wolfe, Cameron R.
    UMass Chan Affiliations
    Department of Medicine, Division of Infectious Diseases and Immunology
    Document Type
    Accepted Manuscript
    Publication Date
    2021-07-09
    Keywords
    SARS-CoV-2
    COVID-19
    vaccine
    antibodies
    antibody response
    Immunology of Infectious Disease
    Immunoprophylaxis and Therapy
    Immunotherapy
    Infectious Disease
    Microbiology
    Surgical Procedures, Operative
    Virus Diseases
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    Abstract
    Despite emerging data suggesting reduced antibody responses among SOT recipients following SARS-CoV-2 vaccine, critical unanswered questions remain. The clinical implications of the reduced humoral response need to be assessed through prospective studies. Studies are likewise needed to inform which vaccine dosing strategies result in improved immunity and if such approaches maximize protection against severe infection in the vulnerable transplant population.
    Source

    Ison MG, Blumberg E, Halasa N, Kaul D, Theodoropoulos NM, Wolfe CR. Antibodies, boosters and optimizing SARS-CoV-2 vaccine for transplantation: A call for more research. Am J Transplant. 2021 Jul 9. doi: 10.1111/ajt.16758. Epub ahead of print. PMID: 34241964. Link to article on publisher's site

    DOI
    10.1111/ajt.16758
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/27456
    PubMed ID
    34241964
    Related Resources

    Link to Article in PubMed

    Rights
    This article is protected by copyright. All rights reserved. This is a PDF file of an accepted manuscript that has been accepted for publication and posted with a 12-month embargo as allowed by the publisher’s author rights policy at https://authorservices.wiley.com/author-resources/Journal-Authors/licensing/self-archiving.html. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
    ae974a485f413a2113503eed53cd6c53
    10.1111/ajt.16758
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    COVID-19 Publications by UMass Chan Authors

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