• Login
    View Item 
    •   Home
    • UMass Chan Faculty and Staff Research and Publications
    • COVID-19 Publications by UMass Chan Authors
    • View Item
    •   Home
    • UMass Chan Faculty and Staff Research and Publications
    • COVID-19 Publications by UMass Chan Authors
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of eScholarship@UMassChanCommunitiesPublication DateAuthorsUMass Chan AffiliationsTitlesDocument TypesKeywordsThis CollectionPublication DateAuthorsUMass Chan AffiliationsTitlesDocument TypesKeywordsProfilesView

    My Account

    LoginRegister

    Help

    AboutSubmission GuidelinesData Deposit PolicySearchingAccessibilityTerms of UseWebsite Migration FAQ

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Viral proteases: Structure, mechanism and inhibition

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Publisher version
    View Source
    Access full-text PDFOpen Access
    View Source
    Check access options
    Check access options
    Authors
    Zephyr, Jacqueto
    Yilmaz, Nese Kurt
    Schiffer, Celia A.
    UMass Chan Affiliations
    Schiffer Lab
    Department of Biochemistry and Molecular Pharmacology
    Document Type
    Book Chapter
    Publication Date
    2021-11-17
    Keywords
    Coronavirus
    Drug resistance
    Enterovirus
    Flavivirus
    HCV
    HIV-1
    HTLV-1
    Protease inhibitors
    Substrate envelope
    Viral protease
    Biochemistry, Biophysics, and Structural Biology
    Enzymes and Coenzymes
    Infectious Disease
    Virology
    Virus Diseases
    Viruses
    Show allShow less
    
    Metadata
    Show full item record
    Link to Full Text
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595904/
    Abstract
    Viral proteases are diverse in structure, oligomeric state, catalytic mechanism, and substrate specificity. This chapter focuses on proteases from viruses that are relevant to human health: human immunodeficiency virus subtype 1 (HIV-1), hepatitis C (HCV), human T-cell leukemia virus type 1 (HTLV-1), flaviviruses, enteroviruses, and coronaviruses. The proteases of HIV-1 and HCV have been successfully targeted for therapeutics, with picomolar FDA-approved drugs currently used in the clinic. The proteases of HTLV-1 and the other virus families remain emerging therapeutic targets at different stages of the drug development process. This chapter provides an overview of the current knowledge on viral protease structure, mechanism, substrate recognition, and inhibition. Particular focus is placed on recent advances in understanding the molecular basis of diverse substrate recognition and resistance, which is essential toward designing novel protease inhibitors as antivirals.
    Source

    Zephyr J, Kurt Yilmaz N, Schiffer CA. Viral proteases: Structure, mechanism and inhibition. Enzymes. 2021;50:301-333. doi: 10.1016/bs.enz.2021.09.004. Epub 2021 Nov 17. PMID: 34861941; PMCID: PMC8595904. Link to article on publisher's site

    DOI
    10.1016/bs.enz.2021.09.004
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/27529
    PubMed ID
    34861941
    Related Resources

    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1016/bs.enz.2021.09.004
    Scopus Count
    Collections
    COVID-19 Publications by UMass Chan Authors
    Schiffer Lab Publications

    entitlement

    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Lamar Soutter Library, UMass Chan Medical School | 55 Lake Avenue North | Worcester, MA 01655 USA
    Quick Guide | escholarship@umassmed.edu
    Works found in eScholarship@UMassChan are protected by copyright unless otherwise indicated.
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.