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Document Type
Book ChapterPublication Date
2021-11-17Keywords
CoronavirusDrug resistance
Enterovirus
Flavivirus
HCV
HIV-1
HTLV-1
Protease inhibitors
Substrate envelope
Viral protease
Biochemistry, Biophysics, and Structural Biology
Enzymes and Coenzymes
Infectious Disease
Virology
Virus Diseases
Viruses
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Show full item recordAbstract
Viral proteases are diverse in structure, oligomeric state, catalytic mechanism, and substrate specificity. This chapter focuses on proteases from viruses that are relevant to human health: human immunodeficiency virus subtype 1 (HIV-1), hepatitis C (HCV), human T-cell leukemia virus type 1 (HTLV-1), flaviviruses, enteroviruses, and coronaviruses. The proteases of HIV-1 and HCV have been successfully targeted for therapeutics, with picomolar FDA-approved drugs currently used in the clinic. The proteases of HTLV-1 and the other virus families remain emerging therapeutic targets at different stages of the drug development process. This chapter provides an overview of the current knowledge on viral protease structure, mechanism, substrate recognition, and inhibition. Particular focus is placed on recent advances in understanding the molecular basis of diverse substrate recognition and resistance, which is essential toward designing novel protease inhibitors as antivirals.Source
Zephyr J, Kurt Yilmaz N, Schiffer CA. Viral proteases: Structure, mechanism and inhibition. Enzymes. 2021;50:301-333. doi: 10.1016/bs.enz.2021.09.004. Epub 2021 Nov 17. PMID: 34861941; PMCID: PMC8595904. Link to article on publisher's site
DOI
10.1016/bs.enz.2021.09.004Permanent Link to this Item
http://hdl.handle.net/20.500.14038/27529PubMed ID
34861941Related Resources
ae974a485f413a2113503eed53cd6c53
10.1016/bs.enz.2021.09.004