COVID-19 and antiphospholipid antibodies: A position statement and management guidance from AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION)
| dc.contributor.author | Wang, Xin | |
| dc.contributor.author | Gkrouzman, Elena | |
| dc.contributor.author | APS-ACTION | |
| dc.date | 2022-08-11T08:08:11.000 | |
| dc.date.accessioned | 2022-08-23T15:45:39Z | |
| dc.date.available | 2022-08-23T15:45:39Z | |
| dc.date.issued | 2021-12-16 | |
| dc.date.submitted | 2022-04-07 | |
| dc.identifier.citation | <p>Wang X, Gkrouzman E, Andrade DCO, Andreoli L, Barbhaiya M, Belmont HM, Branch DW, de Jesús GR, Efthymiou M, Ríos-Garcés R, Gerosa M, El Hasbani G, Knight J, Meroni PL, Pazzola G, Petri M, Rand J, Salmon J, Tektonidou M, Tincani A, Uthman IW, Zuily S, Zuo Y, Lockshin M, Cohen H, Erkan D; APS ACTION. COVID-19 and antiphospholipid antibodies: A position statement and management guidance from AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION). Lupus. 2021 Dec;30(14):2276-2285. doi: 10.1177/09612033211062523. Epub 2021 Dec 16. PMID: 34915764. <a href="https://doi.org/10.1177/09612033211062523">Link to article on publisher's site</a></p> | |
| dc.identifier.issn | 0961-2033 (Linking) | |
| dc.identifier.doi | 10.1177/09612033211062523 | |
| dc.identifier.pmid | 34915764 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14038/27578 | |
| dc.description | <p>Full author list omitted for brevity. For the full list of authors, see article.</p> | |
| dc.description.abstract | Coronavirus disease 2019 (COVID-19) is associated with a high rate of thrombosis. Prolonged activated partial thromboplastin times (aPTT) and antiphospholipid antibodies (aPL) are reported in COVID-19 patients. The majority of publications have not reported whether patients develop clinically relevant persistent aPL, and the clinical significance of new aPL-positivity in COVID-19 is currently unknown. However, the reports of aPL-positivity in COVID-19 raised the question whether common mechanisms exist in the pathogenesis of COVID-19 and antiphospholipid syndrome (APS). In both conditions, thrombotic microangiopathy resulting in microvascular injury and thrombosis is hypothesized to occur through multiple pathways, including endothelial damage, complement activation, and release of neutrophil extracellular traps (NETosis). APS-ACTION, an international APS research network, created a COVID-19 working group that reviewed common mechanisms, positive aPL tests in COVID-19 patients, and implications of COVID-19 infection for patients with known aPL positivity or APS, with the goals of proposing guidance for clinical management and monitoring of aPL-positive COVID-19 patients. This guidance also serves as a call and focus for clinical and basic scientific research. | |
| dc.language.iso | en_US | |
| dc.relation | <p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=34915764&dopt=Abstract">Link to Article in PubMed</a></p> | |
| dc.relation.url | https://doi.org/10.1177/09612033211062523 | |
| dc.subject | Antiphospholipid antibodies | |
| dc.subject | COVID-19 | |
| dc.subject | Hughes syndrome | |
| dc.subject | anticoagulation | |
| dc.subject | antiphospholipid syndrome | |
| dc.subject | lupus anticoagulant | |
| dc.subject | thrombosis | |
| dc.subject | Immune System Diseases | |
| dc.subject | Immunology and Infectious Disease | |
| dc.subject | Infectious Disease | |
| dc.subject | Microbiology | |
| dc.subject | Skin and Connective Tissue Diseases | |
| dc.subject | Virus Diseases | |
| dc.title | COVID-19 and antiphospholipid antibodies: A position statement and management guidance from AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) | |
| dc.type | Journal Article | |
| dc.source.journaltitle | Lupus | |
| dc.source.volume | 30 | |
| dc.source.issue | 14 | |
| dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/covid19/378 | |
| dc.identifier.contextkey | 28518641 | |
| html.description.abstract | <p>Coronavirus disease 2019 (COVID-19) is associated with a high rate of thrombosis. Prolonged activated partial thromboplastin times (aPTT) and antiphospholipid antibodies (aPL) are reported in COVID-19 patients. The majority of publications have not reported whether patients develop clinically relevant persistent aPL, and the clinical significance of new aPL-positivity in COVID-19 is currently unknown. However, the reports of aPL-positivity in COVID-19 raised the question whether common mechanisms exist in the pathogenesis of COVID-19 and antiphospholipid syndrome (APS). In both conditions, thrombotic microangiopathy resulting in microvascular injury and thrombosis is hypothesized to occur through multiple pathways, including endothelial damage, complement activation, and release of neutrophil extracellular traps (NETosis). APS-ACTION, an international APS research network, created a COVID-19 working group that reviewed common mechanisms, positive aPL tests in COVID-19 patients, and implications of COVID-19 infection for patients with known aPL positivity or APS, with the goals of proposing guidance for clinical management and monitoring of aPL-positive COVID-19 patients. This guidance also serves as a call and focus for clinical and basic scientific research.</p> | |
| dc.identifier.submissionpath | covid19/378 | |
| dc.contributor.department | Department of Medicine, Division of Rheumatology | |
| dc.source.pages | 2276-2285 |
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