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Potential Role of Platelets in COVID‐19: Implications for Thrombosis

dc.contributor.authorKoupenova, Milka
dc.date2022-08-11T08:08:11.000
dc.date.accessioned2022-08-23T15:45:45Z
dc.date.available2022-08-23T15:45:45Z
dc.date.issued2020-05-29
dc.date.submitted2020-06-11
dc.identifier.citation<p>Koupenova M. Potential Role of Platelets in COVID‐19: Implications for Thrombosis. Res Pract Thromb Haemost. 2020 May 29:10.1002/rth2.12397. doi: 10.1002/rth2.12397. PMCID: PMC7283793. <a href="https://doi.org/10.1002/rth2.12397" target="_blank" title="Link to article on publisher website">Link to article on publisher website</a></p>
dc.identifier.doi10.1002/rth2.12397
dc.identifier.pmid32685881
dc.identifier.urihttp://hdl.handle.net/20.500.14038/27599
dc.description.abstractFor the past 150 years, platelets have been recognized as the major blood component that mediates hemostasis and thrombosis. In more recent years, however, we have come to appreciate that platelets also perform profound immune functions during infection with various pathogens. We now recognize that platelets can also mediate a response to various RNA viruses such as influenza and that many viral infections, including the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), can affect platelet count. Thrombocytopenia and increased coagulation have been independently associated with increased mortality. This article provides a perspective on the potential roles of platelets during COVID‐19.
dc.language.isoen_US
dc.rightsThis is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectplatelets
dc.subjectCOVID-19
dc.subjectSARS-CoV-2
dc.subjectimmunity
dc.subjectthrombosis
dc.subjectCardiology
dc.subjectCardiovascular Diseases
dc.subjectFluids and Secretions
dc.subjectImmunology and Infectious Disease
dc.subjectInfectious Disease
dc.subjectVirus Diseases
dc.titlePotential Role of Platelets in COVID‐19: Implications for Thrombosis
dc.typeAccepted Manuscript
dc.source.journaltitleResearch and Practice in Thrombosis and Haemostasis
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1053&amp;context=covid19&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/covid19/50
dc.identifier.contextkey18063301
refterms.dateFOA2022-08-23T15:45:45Z
html.description.abstract<p>For the past 150 years, platelets have been recognized as the major blood component that mediates hemostasis and thrombosis. In more recent years, however, we have come to appreciate that platelets also perform profound immune functions during infection with various pathogens. We now recognize that platelets can also mediate a response to various RNA viruses such as influenza and that many viral infections, including the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), can affect platelet count. Thrombocytopenia and increased coagulation have been independently associated with increased mortality. This article provides a perspective on the potential roles of platelets during COVID‐19.</p>
dc.identifier.submissionpathcovid19/50
dc.contributor.departmentDepartment of Medicine, Division of Cardiovascular Medicine


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This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
Except where otherwise noted, this item's license is described as This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.